Linked Life Data

11095514

Source:http://linkedlifedata.com/resource/pubmed/id/11095514

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
16
pubmed:dateCreated
2001-3-6
pubmed:abstractText
The level of serotonin (5-HT) and its major metabolite 5-hydroxyindoleacetic acid (5-HIAA) in dorsal horn of spinal cord and periaqueductal gray (PAG) were measured using in vivo microdialysis coupled with high performance liquid chromatography and electrochemical detection. Intraplantar injection of carrageenan was used to evoke release. Extracellular concentrations of 5-HT and 5-HIAA in spinal dorsal horn and PAG significantly increased following carrageenan inflammation. The peak occurred at 3h and then gradually returned to baseline at 5-7h. The carrageenan-induced release of 5-HT and 5-HIAA in spinal cord rather than in PAG was decreased by intracerebroventricular (i.c.v.) injection of naloxone, and both in spinal dorsal horn and PAG, the release was increased by i.c.v. injection of bicuculine. These results suggest that activity of 5-HT in spinal cord and PAG increases with carrageenan inflammation; the carrageenan-induced release of 5-HT and 5-HIAA in spinal cord may be tonically modulated by supraspinal opioid and GABA systems, whereas the release in PAG may only be tonically modulated by endogenous GABA system in supraspinal level.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0959-4965
pubmed:author
pubmed:issnType
Print
pubmed:day
9
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3539-43
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
The release of serotonin in rat spinal dorsal horn and periaqueductal gray following carrageenan inflammation.
pubmed:affiliation
Department of Neurobiology, Medical Center of Fudan University, Shanghai, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't