Linked Life Data

11095489

Source:http://linkedlifedata.com/resource/pubmed/id/11095489

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
16
pubmed:dateCreated
2001-3-6
pubmed:abstractText
This brief review has highlighted some of the major advances in the last decade or so in understanding the central control of puberty. These include the discovery that GnRH-I neurons develop in the olfactory placode and migrate into the forebrain, the recognition that puberty is a reactivation of GnRH secretion, the identification of leptin as a metabolic signal which may permit puberty to occur, unraveling the molecular basis of the circadian clock which underlies photoperiodic control of puberty in seasonal species, the identification of the structure of pheromones in urine, and the discovery of other populations of GnRH neurons in mammals expressing the GnRH-II gene. Such advances generate further questions: what regulates the migratory pathways of GnRH neurons, and what controls axon outgrowth and targeting to the median eminence? What is the mechanism which causes GnRH secretion to decline between the neonatal and pubertal phase of development? How do leptin and other sensory inputs finally communicate to the GnRH neuron? How do GnRH neurons communicate with each other such that co-ordinated pulsatile release of GnRH occurs? What is the function of GnRH-II? Some of these issues may be better addressed using the transgenic technologies which allow the identification and thus the recording, sampling and observation of GnRH neurons in living tissue, but in order to understand how internal and external cues influence puberty it will also be important to study a variety of other mammalian models in which the relative importance of such inputs differs.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0959-4965
pubmed:author
pubmed:issnType
Print
pubmed:day
9
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
R23-33
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
The neurobiology of reproductive development.
pubmed:affiliation
School of Biomedical Sciences, University of Nottingham, Queens Medical Centre, UK.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't