Source:http://linkedlifedata.com/resource/pubmed/id/11095024
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
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| pubmed:dateCreated |
2001-2-27
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| pubmed:abstractText |
Cystatin C is a non-glycated, 13-kDa basic protein produced by all nucleated cells. Recent studies have indicated that the plasma concentration of cystatin C is a better marker for glomerular filtration rate (GFR) than plasma creatinine, which is most commonly used for this purpose. We established reference values for plasma cystatin C in pre- or full-term infants and children. For comparison we also measured the creatinine concentration in the same samples. Cystatin C was measured by a commercially available immunoturbidimetric method with a Hitachi 704 analyzer in sera obtained from 58 pre-term infants, 50 full-term infants and 299 older children (132 girls, 167 boys, median age 4.17 years, range 8 days to 16 years). No sex differences were found. The pre-term infants had higher cystatin C concentrations (mean 1.88 mg/l, SD 0.36 mg/l) than the full-term (mean 1.70 mg/l, SD 0.26 mg/l, P=0.0145). The reference interval for pre-term infants calculated non-parametrically was 1.34-2.57 mg/l and for full-term infants 1.36-2.23 mg/l. The cystatin C concentration decreased rapidly after birth, and above 3 years of age did not depend on age. The reference interval for children 3-16 years of age calculated non-parametrically was 0.51-1.31 mg/l. Younger children (<1 year: 0.75-1.87 mg/l; 1-3 years: 0.68-1.60 mg/l) had slightly, but significantly, higher plasma cystatin C levels.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
0931-041X
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
15
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
105-8
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:11095024-Adolescent,
pubmed-meshheading:11095024-Aging,
pubmed-meshheading:11095024-Child,
pubmed-meshheading:11095024-Child, Preschool,
pubmed-meshheading:11095024-Creatinine,
pubmed-meshheading:11095024-Cystatin C,
pubmed-meshheading:11095024-Cystatins,
pubmed-meshheading:11095024-Female,
pubmed-meshheading:11095024-Glomerular Filtration Rate,
pubmed-meshheading:11095024-Humans,
pubmed-meshheading:11095024-Infant, Newborn,
pubmed-meshheading:11095024-Infant, Premature,
pubmed-meshheading:11095024-Male,
pubmed-meshheading:11095024-Nephelometry and Turbidimetry,
pubmed-meshheading:11095024-Reference Values,
pubmed-meshheading:11095024-Regression Analysis,
pubmed-meshheading:11095024-Sex Factors,
pubmed-meshheading:11095024-Statistics, Nonparametric
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
Reference intervals for cystatin C in pre- and full-term infants and children.
|
| pubmed:affiliation |
Centre for Laboratory Medicine, Tampere University Hospital, Finland. aimo.harmoinen@tays.fi
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|