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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2000-12-22
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pubmed:abstractText |
The hexosamine biosynthesis pathway acts as a cellular glucose sensor and mediates many of the adverse effects of glucose. Increased flux through this pathway results in insulin resistance in rat fibroblasts and transgenic mice and upregulation of transforming growth factor beta (TGF-beta) transcriptional activity in rat kidney cells. The first and rate-limiting step in this pathway, which is responsible for the metabolism of glucose to glucosamine, is catalyzed by glutamine:fructose-6-phosphate amidotransferase (GFA).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP-Dependent Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Fructosephosphates,
http://linkedlifedata.com/resource/pubmed/chemical/Glucosamine,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose-6-Phosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamine,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamine-Fructose-6-Phosphate...,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor I,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/fructose-6-phosphate,
http://linkedlifedata.com/resource/pubmed/chemical/glucosamine 6-phosphate
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1081-5589
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
427-34
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11094865-Angiotensin II,
pubmed-meshheading:11094865-Animals,
pubmed-meshheading:11094865-Cells, Cultured,
pubmed-meshheading:11094865-Cyclic AMP-Dependent Protein Kinases,
pubmed-meshheading:11094865-Down-Regulation,
pubmed-meshheading:11094865-Fructosephosphates,
pubmed-meshheading:11094865-Glomerular Mesangium,
pubmed-meshheading:11094865-Glucosamine,
pubmed-meshheading:11094865-Glucose,
pubmed-meshheading:11094865-Glucose-6-Phosphate,
pubmed-meshheading:11094865-Glutamine,
pubmed-meshheading:11094865-Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing),
pubmed-meshheading:11094865-Insulin-Like Growth Factor I,
pubmed-meshheading:11094865-Rats,
pubmed-meshheading:11094865-Transforming Growth Factor beta
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pubmed:year |
2000
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pubmed:articleTitle |
Regulation of glutamine:fructose-6-phosphate amidotransferase activity by high glucose and transforming growth factor beta in rat mesangial cells.
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pubmed:affiliation |
Department of Medicine, University of Mississippi Medical Center, Jackson 39216, USA. ecrook@medicine.umsmed.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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