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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
22
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pubmed:dateCreated |
2000-11-30
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pubmed:abstractText |
Endothelin (ET)-1 plays an important role in the pathogenesis of deoxycorticosterone acetate (DOCA)-salt-induced hypertension. We evaluated the pathological role of ET(B) receptors in DOCA-salt-induced hypertension, cardiovascular hypertrophy, and renal damage by using the spotting-lethal (sl) rat, which carries a naturally occurring deletion in the ET(B) receptor gene.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
28
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pubmed:volume |
102
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2765-73
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11094045-Acetylglucosaminidase,
pubmed-meshheading:11094045-Animals,
pubmed-meshheading:11094045-Animals, Genetically Modified,
pubmed-meshheading:11094045-Aorta,
pubmed-meshheading:11094045-Blood Pressure,
pubmed-meshheading:11094045-Blood Urea Nitrogen,
pubmed-meshheading:11094045-Body Weight,
pubmed-meshheading:11094045-Desoxycorticosterone,
pubmed-meshheading:11094045-Endothelin-1,
pubmed-meshheading:11094045-Heart,
pubmed-meshheading:11094045-Hypertension,
pubmed-meshheading:11094045-Kidney,
pubmed-meshheading:11094045-Organ Size,
pubmed-meshheading:11094045-Rats,
pubmed-meshheading:11094045-Rats, Mutant Strains,
pubmed-meshheading:11094045-Receptor, Endothelin B,
pubmed-meshheading:11094045-Receptors, Endothelin,
pubmed-meshheading:11094045-Systole,
pubmed-meshheading:11094045-Time Factors
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pubmed:year |
2000
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pubmed:articleTitle |
Exaggerated vascular and renal pathology in endothelin-B receptor-deficient rats with deoxycorticosterone acetate-salt hypertension.
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pubmed:affiliation |
Department of Pharmacology, Osaka University of Pharmaceutical Sciences, Nasahara, Takatsuki, Osaka, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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