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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1979-9-17
|
| pubmed:abstractText |
The 4-vinyl, 4-ethyl, and three 4-[beta-(arylthio)ethyl] derivatives of primaquine and other 8-aminoquinoline antimalarial agents were prepared for antimalarial evaluation. 8-[(4'-Amino-1'-methylbutyl)amino]-4-ethyl-6-methoxyquinoline (4-ethylprimaquine), which showed activity approximately equal to that of primaquine against Plasmodia cynomolgi in Rhesus monkey, was the most active of the compounds tested. 4-Ethylprimaquine was also less toxic than primaquine, as measured in the Rane mouse screen.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0022-2623
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
22
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
694-9
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:110932-Aminoquinolines,
pubmed-meshheading:110932-Animals,
pubmed-meshheading:110932-Antimalarials,
pubmed-meshheading:110932-Dose-Response Relationship, Drug,
pubmed-meshheading:110932-Haplorhini,
pubmed-meshheading:110932-Macaca mulatta,
pubmed-meshheading:110932-Malaria,
pubmed-meshheading:110932-Mice,
pubmed-meshheading:110932-Plasmodium berghei,
pubmed-meshheading:110932-Primaquine
|
| pubmed:year |
1979
|
| pubmed:articleTitle |
Synthesis of some 4-substituted 8-amino-6-methoxyquinolines as potential antimalarials.
|
| pubmed:publicationType |
Journal Article
|