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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2001-3-15
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pubmed:abstractText |
Tacrolimus (TAC) is a useful immunosuppressive agent in the prevention of rejection. However, the blood level between its therapeutic and toxic levels is narrow such that its nephrotoxicity is a problem. Moreover, its bioavailability and pharmacokinetics are highly variable. We experienced a case of acute nephrotoxicity, in which the blood level rose about 10 times above the expected level. We found a peculiar vacuolization in the transplant biopsy specimen. This change showed a marked vacuolization of the tubular cells, suggestive of acute nephrotoxicity by TAC.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0902-0063
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pubmed:author |
pubmed-author:ChikamotoHH,
pubmed-author:HattoriMM,
pubmed-author:HoritaSS,
pubmed-author:ItoKK,
pubmed-author:MatsumotoNN,
pubmed-author:OonishiMM,
pubmed-author:ShiragaHH,
pubmed-author:SuzukiTT,
pubmed-author:TanabeKK,
pubmed-author:TokumotoTT,
pubmed-author:TomaHH,
pubmed-author:WatanabeSS,
pubmed-author:YamaguchiYY
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pubmed:issnType |
Print
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pubmed:volume |
14 Suppl 3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
30-2
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:11092350-Adolescent,
pubmed-meshheading:11092350-Biopsy,
pubmed-meshheading:11092350-Humans,
pubmed-meshheading:11092350-Immunosuppressive Agents,
pubmed-meshheading:11092350-Kidney Transplantation,
pubmed-meshheading:11092350-Kidney Tubules,
pubmed-meshheading:11092350-Male,
pubmed-meshheading:11092350-Microscopy, Electron,
pubmed-meshheading:11092350-Tacrolimus,
pubmed-meshheading:11092350-Vacuoles
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pubmed:year |
2000
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pubmed:articleTitle |
A peculiar vacuolization in the kidney transplant of a child treated with tacrolimus.
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pubmed:affiliation |
Department of Pediatric Nephrology, Tokyo Women's Medical University, Japan. swata@kc.twmu.ac.jp
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pubmed:publicationType |
Journal Article,
Case Reports
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