Source:http://linkedlifedata.com/resource/pubmed/id/11089908
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
10
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pubmed:dateCreated |
2001-2-23
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pubmed:abstractText |
It is not known whether the amelioration of inflammation by corticosteroids is mediated through a direct effect on the T cells or by effects on other inflammatory cells and/or their products. To explore the mechanisms whereby corticosteroids exert their effects on T cell dependent inflammation we have used severe combined immunodeficiency (SCID) mice. These mice are largely devoid of functional T and B lymphocytes, hence being unable to raise delayed type hypersensitivity (DTH), but display intact antigen presenting capacity. The aim of this study was to analyse the target cell population participating in DTH and being affected by corticosteroid treatment.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1023-3830
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
49
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
548-52
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11089908-Adoptive Transfer,
pubmed-meshheading:11089908-Animals,
pubmed-meshheading:11089908-Dexamethasone,
pubmed-meshheading:11089908-Down-Regulation,
pubmed-meshheading:11089908-Female,
pubmed-meshheading:11089908-Hypersensitivity, Delayed,
pubmed-meshheading:11089908-Mice,
pubmed-meshheading:11089908-Mice, Inbred C57BL,
pubmed-meshheading:11089908-Mice, SCID,
pubmed-meshheading:11089908-T-Lymphocytes
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pubmed:year |
2000
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pubmed:articleTitle |
Action of dexamethasone in the suppression of delayed-type hypersensitivity in reconstituted SCID mice.
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pubmed:affiliation |
Department of Rheumatology, University of Göteborg, Sweden. maria.taube@immuno.gu.se
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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