Source:http://linkedlifedata.com/resource/pubmed/id/11086721
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
22
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| pubmed:dateCreated |
2001-2-12
|
| pubmed:abstractText |
Galloy esters with 'substrate-like' isoprenoid or phenylalkyl side chains were newly synthesized and tested for the enzyme inhibition activities toward recombinant rat squalene epoxidase. Isoprenyl gallates (4-6) showed good inhibition (IC50 = 1.5 5.1 microM), as potent as previously reported substrate analogues, while phenylalkyl gallates (7-10) were moderate inhibitors of the enzyme (IC50 = 12-61 microM).
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0960-894X
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
20
|
| pubmed:volume |
10
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2525-8
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11086721-Animals,
pubmed-meshheading:11086721-Enzyme Inhibitors,
pubmed-meshheading:11086721-Gallic Acid,
pubmed-meshheading:11086721-Magnetic Resonance Spectroscopy,
pubmed-meshheading:11086721-Mass Spectrometry,
pubmed-meshheading:11086721-Oxygenases,
pubmed-meshheading:11086721-Rats,
pubmed-meshheading:11086721-Squalene Monooxygenase
|
| pubmed:year |
2000
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| pubmed:articleTitle |
Inhibition of vertebrate squalene epoxidase by isoprenyl gallates and phenylalkyl gallates.
|
| pubmed:affiliation |
University of Shizuoka, School of Pharmaceutical Sciences, Yida, Japan. abei@ys7.u-shizuoka-ken.ac.jp
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|