| pubmed-article:11085523 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11085523 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:11085523 | lifeskim:mentions | umls-concept:C0999806 | lld:lifeskim |
| pubmed-article:11085523 | lifeskim:mentions | umls-concept:C0851140 | lld:lifeskim |
| pubmed-article:11085523 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:11085523 | lifeskim:mentions | umls-concept:C0033522 | lld:lifeskim |
| pubmed-article:11085523 | lifeskim:mentions | umls-concept:C0443252 | lld:lifeskim |
| pubmed-article:11085523 | pubmed:issue | 21 | lld:pubmed |
| pubmed-article:11085523 | pubmed:dateCreated | 2000-11-20 | lld:pubmed |
| pubmed-article:11085523 | pubmed:abstractText | Human papillomavirus 16 (HPV16) is a predominant cause of cervical neoplasia. However, no population-based study with long-term follow-up has clarified the temporal relationship between HPV16 infection and occurrence of carcinoma in situ, or the importance of recurrent or persistent infection. This nested case-control study was carried out in a population-based cohort of women participating in cytological screening whose initial smear, taken in 1969-1995, was normal. During up to 26 years of follow-up, carcinoma in situ was diagnosed in 484 eligible women. Archival smears from these women were compared with smears from 619 individually matched controls. After DNA extraction, a highly sensitive PCR system was used to detect HPV16. Among case women, the prevalence of HPV16 positivity was 56% at the time of diagnosis. The relative risk of cervical carcinoma in situ increased from 3.6 (95% confidence interval, 1.2-11.0) 13 years before diagnosis to 11.1 (95% confidence interval, 5.5-22.2) 1 year before diagnosis. Having a positive smear at entry to the cohort increased risk >5-fold, whereas having persistent infection with HPV in two subsequent smears increased risk 30-fold. We estimated that among HPV16-positive women, the median incubation period from infection to carcinoma in situ was 7-12 years. We conclude that evidence of persistent and/or recurrent infection is associated with a drastically higher risk of cervical carcinoma in situ than occasional infection with HPV16. | lld:pubmed |
| pubmed-article:11085523 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11085523 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11085523 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11085523 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11085523 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11085523 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:11085523 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:11085523 | pubmed:author | pubmed-author:AndersenP KPK | lld:pubmed |
| pubmed-article:11085523 | pubmed:author | pubmed-author:PonténJJ | lld:pubmed |
| pubmed-article:11085523 | pubmed:author | pubmed-author:AdamiH OHO | lld:pubmed |
| pubmed-article:11085523 | pubmed:author | pubmed-author:GustafssonMM | lld:pubmed |
| pubmed-article:11085523 | pubmed:author | pubmed-author:MagnussonPP | lld:pubmed |
| pubmed-article:11085523 | pubmed:author | pubmed-author:SörensenPP | lld:pubmed |
| pubmed-article:11085523 | pubmed:author | pubmed-author:GyllenstenUU | lld:pubmed |
| pubmed-article:11085523 | pubmed:author | pubmed-author:SparénPP | lld:pubmed |
| pubmed-article:11085523 | pubmed:author | pubmed-author:MelbyeMM | lld:pubmed |
| pubmed-article:11085523 | pubmed:author | pubmed-author:JosefssonAA | lld:pubmed |
| pubmed-article:11085523 | pubmed:author | pubmed-author:FrischMM | lld:pubmed |
| pubmed-article:11085523 | pubmed:author | pubmed-author:YlitaloNN | lld:pubmed |
| pubmed-article:11085523 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11085523 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11085523 | pubmed:volume | 60 | lld:pubmed |
| pubmed-article:11085523 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11085523 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11085523 | pubmed:pagination | 6027-32 | lld:pubmed |
| pubmed-article:11085523 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:11085523 | pubmed:meshHeading | pubmed-meshheading:11085523... | lld:pubmed |
| pubmed-article:11085523 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11085523 | pubmed:articleTitle | A prospective study showing long-term infection with human papillomavirus 16 before the development of cervical carcinoma in situ. | lld:pubmed |
| pubmed-article:11085523 | pubmed:affiliation | Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden. Nathalie.Ylitalo@mep.ki.se | lld:pubmed |
| pubmed-article:11085523 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11085523 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11085523 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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