Source:http://linkedlifedata.com/resource/pubmed/id/11085523
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
21
|
| pubmed:dateCreated |
2000-11-20
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| pubmed:abstractText |
Human papillomavirus 16 (HPV16) is a predominant cause of cervical neoplasia. However, no population-based study with long-term follow-up has clarified the temporal relationship between HPV16 infection and occurrence of carcinoma in situ, or the importance of recurrent or persistent infection. This nested case-control study was carried out in a population-based cohort of women participating in cytological screening whose initial smear, taken in 1969-1995, was normal. During up to 26 years of follow-up, carcinoma in situ was diagnosed in 484 eligible women. Archival smears from these women were compared with smears from 619 individually matched controls. After DNA extraction, a highly sensitive PCR system was used to detect HPV16. Among case women, the prevalence of HPV16 positivity was 56% at the time of diagnosis. The relative risk of cervical carcinoma in situ increased from 3.6 (95% confidence interval, 1.2-11.0) 13 years before diagnosis to 11.1 (95% confidence interval, 5.5-22.2) 1 year before diagnosis. Having a positive smear at entry to the cohort increased risk >5-fold, whereas having persistent infection with HPV in two subsequent smears increased risk 30-fold. We estimated that among HPV16-positive women, the median incubation period from infection to carcinoma in situ was 7-12 years. We conclude that evidence of persistent and/or recurrent infection is associated with a drastically higher risk of cervical carcinoma in situ than occasional infection with HPV16.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0008-5472
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| pubmed:author |
pubmed-author:AdamiH OHO,
pubmed-author:AndersenP KPK,
pubmed-author:FrischMM,
pubmed-author:GustafssonMM,
pubmed-author:GyllenstenUU,
pubmed-author:JosefssonAA,
pubmed-author:MagnussonPP,
pubmed-author:MelbyeMM,
pubmed-author:PonténJJ,
pubmed-author:SörensenPP,
pubmed-author:SparénPP,
pubmed-author:YlitaloNN
|
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
60
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
6027-32
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| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:11085523-Adolescent,
pubmed-meshheading:11085523-Adult,
pubmed-meshheading:11085523-Aged,
pubmed-meshheading:11085523-Carcinoma, Squamous Cell,
pubmed-meshheading:11085523-Carcinoma in Situ,
pubmed-meshheading:11085523-Case-Control Studies,
pubmed-meshheading:11085523-Cohort Studies,
pubmed-meshheading:11085523-Female,
pubmed-meshheading:11085523-Follow-Up Studies,
pubmed-meshheading:11085523-Humans,
pubmed-meshheading:11085523-Mass Screening,
pubmed-meshheading:11085523-Middle Aged,
pubmed-meshheading:11085523-Papillomaviridae,
pubmed-meshheading:11085523-Papillomavirus Infections,
pubmed-meshheading:11085523-Prevalence,
pubmed-meshheading:11085523-Prospective Studies,
pubmed-meshheading:11085523-Risk Factors,
pubmed-meshheading:11085523-Sweden,
pubmed-meshheading:11085523-Time Factors,
pubmed-meshheading:11085523-Tumor Virus Infections,
pubmed-meshheading:11085523-Uterine Cervical Neoplasms,
pubmed-meshheading:11085523-Vaginal Smears
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
A prospective study showing long-term infection with human papillomavirus 16 before the development of cervical carcinoma in situ.
|
| pubmed:affiliation |
Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden. Nathalie.Ylitalo@mep.ki.se
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|