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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2003-3-10
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pubmed:abstractText |
The effect of zaldaride on acetylcholine-induced colonic electrolyte secretion was examined. The short-circuit current response to acetylcholine was partially reduced by tetrodotoxin, a neuronal blocker, and was completely inhibited by atropine, an acetylcholine M receptor antagonist, in the rat colonic preparations. The tetrodotoxin sensitive effect was significantly inhibited by zaldaride, whereas the tetrodotoxin insensitive effect was not affected. Acetylcholine release from synaptosomes of submucosal nerves of guinea-pig colon was significantly reduced by zaldaride. Zaldaride may reduce colonic electrolyte secretion by acetylcholine due to the inhibition of acetylcholine release from synaptosomes of colonic submucosal nerves.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetylcholine,
http://linkedlifedata.com/resource/pubmed/chemical/Anesthetics, Local,
http://linkedlifedata.com/resource/pubmed/chemical/Antidiarrheals,
http://linkedlifedata.com/resource/pubmed/chemical/Benzimidazoles,
http://linkedlifedata.com/resource/pubmed/chemical/CGS 9343B,
http://linkedlifedata.com/resource/pubmed/chemical/Electrolytes,
http://linkedlifedata.com/resource/pubmed/chemical/Muscarinic Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Muscarinic,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrodotoxin
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0918-6158
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1377-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11085370-Acetylcholine,
pubmed-meshheading:11085370-Anesthetics, Local,
pubmed-meshheading:11085370-Animals,
pubmed-meshheading:11085370-Antidiarrheals,
pubmed-meshheading:11085370-Benzimidazoles,
pubmed-meshheading:11085370-Colon,
pubmed-meshheading:11085370-Diffusion Chambers, Culture,
pubmed-meshheading:11085370-Electrolytes,
pubmed-meshheading:11085370-Electrophysiology,
pubmed-meshheading:11085370-Guinea Pigs,
pubmed-meshheading:11085370-Intestines,
pubmed-meshheading:11085370-Male,
pubmed-meshheading:11085370-Muscarinic Antagonists,
pubmed-meshheading:11085370-Rats,
pubmed-meshheading:11085370-Rats, Sprague-Dawley,
pubmed-meshheading:11085370-Receptors, Muscarinic,
pubmed-meshheading:11085370-Synaptosomes,
pubmed-meshheading:11085370-Tetrodotoxin
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pubmed:year |
2000
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pubmed:articleTitle |
The effect of zaldaride maleate, an antidiarrheal compound, on acetylcholine-induced intestinal electrolyte secretion.
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pubmed:affiliation |
The Drug Development Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd., 1188 Shimotogari, Nagaizumi-cho, Sunto-gun, Shizuoka, Japan. AIKAWA@kyowa.co.jp
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pubmed:publicationType |
Journal Article,
In Vitro
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