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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
21
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pubmed:dateCreated |
2000-11-29
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pubmed:abstractText |
Anaphase-promoting complex (APC)/cyclosome and 26S proteasome are respectively required for polyubiquitination and degradation of mitotic cyclin and anaphase inhibitor Cut2 (Pds1/securin). In fission yeast, mutant cells defective in cyclosome and proteasome fail to complete mitosis and have hypercondensed chromosomes and a short spindle. A similar phenotype is seen in a temperature-sensitive strain cut8-563 at 36 degrees C, but the molecular basis for Cut8 function is little understood.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ATP dependent 26S protease,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cut2 protein, S pombe,
http://linkedlifedata.com/resource/pubmed/chemical/Cut8 protein, S pombe,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclins,
http://linkedlifedata.com/resource/pubmed/chemical/Cycloheximide,
http://linkedlifedata.com/resource/pubmed/chemical/Fungal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Hydrolases,
http://linkedlifedata.com/resource/pubmed/chemical/Proteasome Endopeptidase Complex,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Synthesis Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Schizosaccharomyces pombe Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ubiquitins
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0960-9822
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1329-38
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11084332-Anaphase,
pubmed-meshheading:11084332-Cell Cycle Proteins,
pubmed-meshheading:11084332-Cell Nucleus,
pubmed-meshheading:11084332-Cyclins,
pubmed-meshheading:11084332-Cycloheximide,
pubmed-meshheading:11084332-Fungal Proteins,
pubmed-meshheading:11084332-G1 Phase,
pubmed-meshheading:11084332-Gene Deletion,
pubmed-meshheading:11084332-Genes, Reporter,
pubmed-meshheading:11084332-Microscopy, Fluorescence,
pubmed-meshheading:11084332-Mitotic Spindle Apparatus,
pubmed-meshheading:11084332-Mutation,
pubmed-meshheading:11084332-Peptide Hydrolases,
pubmed-meshheading:11084332-Proteasome Endopeptidase Complex,
pubmed-meshheading:11084332-Protein Synthesis Inhibitors,
pubmed-meshheading:11084332-Schizosaccharomyces,
pubmed-meshheading:11084332-Schizosaccharomyces pombe Proteins,
pubmed-meshheading:11084332-Temperature,
pubmed-meshheading:11084332-Ubiquitins
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pubmed:year |
2000
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pubmed:articleTitle |
Cut8, essential for anaphase, controls localization of 26S proteasome, facilitating destruction of cyclin and Cut2.
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pubmed:affiliation |
CREST Research Project, Department of Biophysics, Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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