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rdf:type |
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lifeskim:mentions |
umls-concept:C0003320,
umls-concept:C0016993,
umls-concept:C0026926,
umls-concept:C0030705,
umls-concept:C0039194,
umls-concept:C0041296,
umls-concept:C0085358,
umls-concept:C0086418,
umls-concept:C0205369,
umls-concept:C1327616,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1706438,
umls-concept:C2587213,
umls-concept:C2698600
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pubmed:issue |
12
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pubmed:dateCreated |
2000-12-13
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pubmed:abstractText |
Intracellular flow cytometry analysis of perforin production by CD8(+) T cells showed levels were greatly reduced in tuberculosis (TB) patients compared to healthy controls. Reduced cytotoxic-T-lymphocyte activity was also obtained with CD8(+) T cells from TB patients compared to healthy controls in The Gambia. A change in antigen recognition was noted between the two groups of donors: in addition to recognition of Ag85A and Ag85B, as seen in healthy donors, a prominent ESAT-6 response was found in TB patients.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083843-10069419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083843-10496899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083843-1465432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083843-1970071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083843-7807661,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083843-7875199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083843-7897219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083843-8501346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083843-8557334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083843-8778016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083843-8975902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083843-9009330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083843-9119468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083843-9200465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083843-9370917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083843-9418128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083843-9419365,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083843-9435310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083843-9453632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083843-9529077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083843-9584141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083843-9725236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083843-9862331,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083843-9886408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083843-9952370
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7144-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11083843-Adult,
pubmed-meshheading:11083843-Antigens, Bacterial,
pubmed-meshheading:11083843-BCG Vaccine,
pubmed-meshheading:11083843-Humans,
pubmed-meshheading:11083843-Male,
pubmed-meshheading:11083843-Membrane Glycoproteins,
pubmed-meshheading:11083843-Mycobacterium tuberculosis,
pubmed-meshheading:11083843-Perforin,
pubmed-meshheading:11083843-Pore Forming Cytotoxic Proteins,
pubmed-meshheading:11083843-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:11083843-Tuberculosis,
pubmed-meshheading:11083843-Vaccination
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pubmed:year |
2000
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pubmed:articleTitle |
Human CD8(+) T cells specific for Mycobacterium tuberculosis secreted antigens in tuberculosis patients and healthy BCG-vaccinated controls in The Gambia.
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pubmed:affiliation |
Immunology Unit, London School of Hygiene & Tropical Medicine, London, United Kingdom. steven.smith@lshtm.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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