| pubmed-article:11083661 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11083661 | lifeskim:mentions | umls-concept:C0028778 | lld:lifeskim |
| pubmed-article:11083661 | lifeskim:mentions | umls-concept:C0086045 | lld:lifeskim |
| pubmed-article:11083661 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:11083661 | lifeskim:mentions | umls-concept:C0028630 | lld:lifeskim |
| pubmed-article:11083661 | lifeskim:mentions | umls-concept:C0040077 | lld:lifeskim |
| pubmed-article:11083661 | lifeskim:mentions | umls-concept:C1955880 | lld:lifeskim |
| pubmed-article:11083661 | lifeskim:mentions | umls-concept:C0728940 | lld:lifeskim |
| pubmed-article:11083661 | lifeskim:mentions | umls-concept:C1524075 | lld:lifeskim |
| pubmed-article:11083661 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:11083661 | lifeskim:mentions | umls-concept:C0015252 | lld:lifeskim |
| pubmed-article:11083661 | lifeskim:mentions | umls-concept:C0205463 | lld:lifeskim |
| pubmed-article:11083661 | lifeskim:mentions | umls-concept:C0243071 | lld:lifeskim |
| pubmed-article:11083661 | lifeskim:mentions | umls-concept:C0332206 | lld:lifeskim |
| pubmed-article:11083661 | lifeskim:mentions | umls-concept:C0150312 | lld:lifeskim |
| pubmed-article:11083661 | lifeskim:mentions | umls-concept:C0146894 | lld:lifeskim |
| pubmed-article:11083661 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:11083661 | pubmed:dateCreated | 2000-11-30 | lld:pubmed |
| pubmed-article:11083661 | pubmed:abstractText | Removal of 2',3'-didehydro-3'-deoxythymidine-5'-monophosphate (d4TMP) from a blocked DNA chain can occur through transfer of the chain-terminating residue to a nucleotide acceptor by human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT). ATP-dependent removal of either d4TMP or 3'-azido-3'-deoxythymidine-5'-monophosphate (AZTMP) is increased in AZT resistant HIV-1 RT (containing D67N/K70R/T215F/K219Q mutations). Removal of d4TMP is strongly inhibited by the next complementary deoxynucleoside triphosphate (50% inhibitory concentration [IC(50)] of approximately 0.5 microM), whereas removal of AZTMP is much less sensitive to this inhibition (IC(50) of >100 microM). This could explain the lack of cross-resistance by AZT-resistant HIV-1 to d4T in phenotypic drug susceptibility assays. | lld:pubmed |
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| pubmed-article:11083661 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11083661 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11083661 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11083661 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:11083661 | pubmed:issn | 0066-4804 | lld:pubmed |
| pubmed-article:11083661 | pubmed:author | pubmed-author:ScottW AWA | lld:pubmed |
| pubmed-article:11083661 | pubmed:author | pubmed-author:SchinaziR FRF | lld:pubmed |
| pubmed-article:11083661 | pubmed:author | pubmed-author:MeyerP RPR | lld:pubmed |
| pubmed-article:11083661 | pubmed:author | pubmed-author:SoA GAG | lld:pubmed |
| pubmed-article:11083661 | pubmed:author | pubmed-author:MatsuuraS ESE | lld:pubmed |
| pubmed-article:11083661 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11083661 | pubmed:volume | 44 | lld:pubmed |
| pubmed-article:11083661 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11083661 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11083661 | pubmed:pagination | 3465-72 | lld:pubmed |
| pubmed-article:11083661 | pubmed:dateRevised | 2010-9-29 | lld:pubmed |
| pubmed-article:11083661 | pubmed:meshHeading | pubmed-meshheading:11083661... | lld:pubmed |
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| pubmed-article:11083661 | pubmed:meshHeading | pubmed-meshheading:11083661... | lld:pubmed |
| pubmed-article:11083661 | pubmed:meshHeading | pubmed-meshheading:11083661... | lld:pubmed |
| pubmed-article:11083661 | pubmed:meshHeading | pubmed-meshheading:11083661... | lld:pubmed |
| pubmed-article:11083661 | pubmed:meshHeading | pubmed-meshheading:11083661... | lld:pubmed |
| pubmed-article:11083661 | pubmed:meshHeading | pubmed-meshheading:11083661... | lld:pubmed |
| pubmed-article:11083661 | pubmed:meshHeading | pubmed-meshheading:11083661... | lld:pubmed |
| pubmed-article:11083661 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11083661 | pubmed:articleTitle | Differential removal of thymidine nucleotide analogues from blocked DNA chains by human immunodeficiency virus reverse transcriptase in the presence of physiological concentrations of 2'-deoxynucleoside triphosphates. | lld:pubmed |
| pubmed-article:11083661 | pubmed:affiliation | Department of Biochemistry and Molecular Biology, University of Miami, Miami, Florida 33101-6129, USA. | lld:pubmed |
