Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2000-11-30
pubmed:abstractText
Polymyxins B and E1 and gramicidin S are bacterium-derived cationic antimicrobial peptides. The polymyxins were more potent than gramicidin S against Pseudomonas aeruginosa, with MICs of 0.125 to 0. 25 and 8 microg/ml, respectively. These peptides differed in their affinities for binding to lipopolysaccharide, but all were able to permeabilize the outer membrane of wild-type P. aeruginosa PAO1 strain H103, suggesting differences in their mechanisms of self-promoted uptake. Gramicidin S caused rapid depolarization of the bacterial cytoplasmic membrane at concentrations at which no killing was observed within 30 min, whereas, conversely, the concentrations of the polymyxins that resulted in rapid killing resulted in minimal depolarization. These data indicate that the depolarization of the cytoplasmic membrane by these peptides did not correlate with bacterial cell lethality.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/11083634-10348745, http://linkedlifedata.com/resource/pubmed/commentcorrection/11083634-10353835, http://linkedlifedata.com/resource/pubmed/commentcorrection/11083634-10387056, http://linkedlifedata.com/resource/pubmed/commentcorrection/11083634-118160, http://linkedlifedata.com/resource/pubmed/commentcorrection/11083634-13303920, http://linkedlifedata.com/resource/pubmed/commentcorrection/11083634-169730, http://linkedlifedata.com/resource/pubmed/commentcorrection/11083634-197881, http://linkedlifedata.com/resource/pubmed/commentcorrection/11083634-2437956, http://linkedlifedata.com/resource/pubmed/commentcorrection/11083634-2668334, http://linkedlifedata.com/resource/pubmed/commentcorrection/11083634-3013085, http://linkedlifedata.com/resource/pubmed/commentcorrection/11083634-3027012, http://linkedlifedata.com/resource/pubmed/commentcorrection/11083634-363151, http://linkedlifedata.com/resource/pubmed/commentcorrection/11083634-4842277, http://linkedlifedata.com/resource/pubmed/commentcorrection/11083634-4867931, http://linkedlifedata.com/resource/pubmed/commentcorrection/11083634-6440475, http://linkedlifedata.com/resource/pubmed/commentcorrection/11083634-6687431, http://linkedlifedata.com/resource/pubmed/commentcorrection/11083634-931364, http://linkedlifedata.com/resource/pubmed/commentcorrection/11083634-9867806
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0066-4804
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3317-21
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Interactions of bacterial cationic peptide antibiotics with outer and cytoplasmic membranes of Pseudomonas aeruginosa.
pubmed:affiliation
Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't