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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19 Suppl 3
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pubmed:dateCreated |
2000-11-22
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pubmed:abstractText |
After cardiopulmonary bypass (CPB), altered vascular reactivity is a major source of complications, particularly for children with increased pulmonary blood flow. Although changes in agonist-induced NO activity are well described after CPB, potential changes in basal NO production and their role in post-CPB pulmonary hypertension remain unclear. By using aortopulmonary vascular graft placement in the fetal lamb (shunt lambs), we established a unique model of pulmonary hypertension that mimics congenital heart disease with increased pulmonary blood flow. The objective of the present study was to investigate potential alterations in endogenous NO production after CPB in lambs with normal and increased pulmonary blood flow.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
7
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pubmed:volume |
102
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
III172-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11082382-Animals,
pubmed-meshheading:11082382-Blood Flow Velocity,
pubmed-meshheading:11082382-Blood Pressure,
pubmed-meshheading:11082382-Blotting, Western,
pubmed-meshheading:11082382-Cardiopulmonary Bypass,
pubmed-meshheading:11082382-Cyclic GMP,
pubmed-meshheading:11082382-Disease Models, Animal,
pubmed-meshheading:11082382-Hypertension, Pulmonary,
pubmed-meshheading:11082382-Lung,
pubmed-meshheading:11082382-Nitrates,
pubmed-meshheading:11082382-Nitric Oxide,
pubmed-meshheading:11082382-Nitric Oxide Synthase,
pubmed-meshheading:11082382-Nitric Oxide Synthase Type III,
pubmed-meshheading:11082382-Pulmonary Artery,
pubmed-meshheading:11082382-Pulmonary Circulation,
pubmed-meshheading:11082382-Sheep
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pubmed:year |
2000
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pubmed:articleTitle |
Alterations in endogenous nitric oxide production after cardiopulmonary bypass in lambs with normal and increased pulmonary blood flow.
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pubmed:affiliation |
Department of Cardiothoracic Surgery, University of California, San Francisco, San Francisco, CA 94143-0106, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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