Source:http://linkedlifedata.com/resource/pubmed/id/11081465
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2001-2-9
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| pubmed:abstractText |
Exercise training is known (1) to enhance the function of the GH-IGF-I system, which has profound effects on body fluid status; (2) to increase blood fluidity. Thus, we investigated during an exercise-test in 39 male elite sportsmen (age 23.7+/-0.72 years; body mass index 23.7+/-0.28 kg/m2) the possible relationships between GH and IGF-I status and the rheological properties of blood. Two correlations indicate a relationship between body hydration and fitness: isometric handgrip strength is correlated with the percentage of extracellular water in total body water (r = 0.432, p = 0.02) and the aerobic working capacity W170 is negatively correlated with hematocrit (r = -0.341, p = 0.039). Water loss during exercise appears to be inversely related to fitness as evaluated by W170 (r = -0.529, p = 0.05), and is positively correlated with the score of signs of overtraining (r = 0.725, p = 0.003) and with the red blood cell aggregation index (r = 0.584, p = 0.036). Finally, while the GH peak value is correlated with the extracellular water volume (r = 0.393, p = 0.02), IGF-I is correlated with blood viscosity (r = 0.546, p = 0.0003), suggesting that when IGF-I values are within the upper quintile (>340 ng/ml) IGF-I may unfavourably affect blood rheology. Among factors of blood viscosity, IGF-I exhibits a borderline correlation (p = 0.05) with "Tk" and the ratio IGF1/IGFBP3 which reflects free circulating IGF-I is correlated with red cell aggregability measured with the Myrenne "M" (r = 0.485, p = 0.014) and S60 (r = 0.396, p = 0.494). These findings confirm the importance of hydration and dehydration as determinants of both blood rheology and exercise performance. Moreover, they suggest that values of IGF-I within the upper quintile are associated with an impairment of blood fluidity, possibly due to a direct effect of IGF-I on red cell deformability and aggregability.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
1386-0291
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
22
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
277-86
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:11081465-Adult,
pubmed-meshheading:11081465-Blood Viscosity,
pubmed-meshheading:11081465-Body Water,
pubmed-meshheading:11081465-Dehydration,
pubmed-meshheading:11081465-Erythrocyte Aggregation,
pubmed-meshheading:11081465-Erythrocyte Deformability,
pubmed-meshheading:11081465-Exercise,
pubmed-meshheading:11081465-Exercise Test,
pubmed-meshheading:11081465-Hemorheology,
pubmed-meshheading:11081465-Humans,
pubmed-meshheading:11081465-Insulin-Like Growth Factor Binding Protein 3,
pubmed-meshheading:11081465-Insulin-Like Growth Factor I,
pubmed-meshheading:11081465-Male,
pubmed-meshheading:11081465-Physical Fitness,
pubmed-meshheading:11081465-Sports
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| pubmed:year |
2000
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| pubmed:articleTitle |
Relationships between blood viscosity and insulin-like growth factor I status in athletes.
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| pubmed:affiliation |
Service Central de Physiologie Clinique, Centre d'Exploration et de Réadaptation des Anomalies du Métabolisme Musculaire (CERAMM), CHU Lapeyronie, Montpellier, France.
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| pubmed:publicationType |
Journal Article
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