Linked Life Data

11078929

Source:http://linkedlifedata.com/resource/pubmed/id/11078929

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2001-1-9
pubmed:abstractText
This study investigated the involvement of N- and P/Q-type Ca(2+) channels in sensorimotor transmission and synaptic depression in the in vitro neonatal rat spinal cord preparation. Postsynaptic potentials were intracellularly recorded from spinal motoneurones during stimulation of the dorsal roots. We found that omega-agatoxin-IVA (P/Q-type Ca(2+) channels blocker), omega-conotoxin-GVIA (N-type Ca(2+) channel blocker) and omega-conotoxin-MVIIC (N-, P/Q-type Ca(2+) channel blocker) markedly decreased both poly- and monosynaptic potentials. We also found that the frequency-dependent depression which occurred in the monosynaptic response, for stimulus intervals shorter than 30 s, persisted in the presence of the various Ca(2+) channels blockers. Hyperpolarizing the motoneurons significantly reduced depression, suggesting contribution from some additional postsynaptic mechanisms. We conclude that at birth, as in adult central nervous system (CNS) synapses, several types of voltage dependent calcium channels mediate sensorimotor neurotransmission and that synaptic depression, which is characteristic of neonatal sensorimotor transmission, does not involve these Ca(2+) channels.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
295
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
29-32
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
N- and P/Q-type Ca(2+) channels are involved in neurotransmitter release but not in synaptic depression in the spinal cord of the neonatal rat.
pubmed:affiliation
NBM, CNRS, 31 Chemin Joseph Aiguier, BP 71 13402 Cedex 20, Marseille, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't