Linked Life Data

11077419

Source:http://linkedlifedata.com/resource/pubmed/id/11077419

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2000-12-8
pubmed:abstractText
The restricted expression of the low affinity nerve growth factor receptor p75NTR by olfactory ensheathing cells suggests that this molecule is involved in the development of the olfactory nerve pathway. To begin to understand the role of p75NTR, we examined the development of the primary olfactory system in p75NTR(-/-) and wild-type mice. Our results demonstrate that, although p75NTR is not essential for the initial assembly of the olfactory nerve, it plays an important role in the postnatal maturation of the olfactory bulb. In the absence of p75NTR, there is exuberant growth of some primary olfactory axons into the olfactory bulb. These axons either aberrantly bypass the glomerular layer and project into deeper lamina or grow into an abnormal bleb of tissue protruding from the medial surface of the dorsocaudal olfactory bulb. These blebs become apparent in neonatal mice and contain axons expressing olfactory marker protein that form ectopic glomerular-like tufts. Histochemical staining with the plant lectin Dolichos biflorus agglutinin revealed that axons sorted out and selectively converged on glomeruli within these blebs. Our results suggest that p75NTR indirectly influences axon growth but not glomerular targeting and plays a role in the postnatal maturation of laminar cytoarchitecture in the olfactory bulb.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0021-9967
pubmed:author
pubmed:copyrightInfo
Copyright 2000 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
428
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
656-70
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Primary olfactory axons form ectopic glomeruli in mice lacking p75NTR.
pubmed:affiliation
Department of Anatomy and Cell Biology, University of Melbourne, Victoria 3052, Australia.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't