|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2001-2-2
|
|
pubmed:abstractText |
We investigated pellet-shaped implants prepared from biphasic calcium phosphate (BCP) ceramics with five different ratios of hydroxyapatite (HAP) to beta-tricalcium phosphate (beta-TCP) to evaluate these ceramics as bone substitutes. BCP ceramics impregnated with different doses of recombinant human bone morphogenetic protein 2 (rhBMP-2) (1, 5, and 10 microg) were used for experimental purposes and ceramics without rhBMP-2 were used for control. The pellets were implanted under the pericranium in adult Wistar male rats and were harvested 8 weeks after implantation. The retrieved pellets were then examined radiologically, histologically, and histomorphometrically. The results revealed that the pellets treated with rhBMP-2 exhibited new bone and bone marrow, whereas control pellets produced fibrous connective tissues. The formation of new bone induced by rhBMP-2 was dose dependent. The extent of bone and bone marrow formation and the degree of resorption of the ceramic particles were significantly higher in the pellets composed of 25% HAP-75% TCP. In this study, bioresorption of the ceramic produced favorable conditions for rhBMP-2-induced bone formation.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/BMP1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Biocompatible Materials,
http://linkedlifedata.com/resource/pubmed/chemical/Bmp1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Protein 1,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Substitutes,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Phosphates,
http://linkedlifedata.com/resource/pubmed/chemical/Ceramics,
http://linkedlifedata.com/resource/pubmed/chemical/Durapatite,
http://linkedlifedata.com/resource/pubmed/chemical/Metalloendopeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/beta-tricalcium phosphate,
http://linkedlifedata.com/resource/pubmed/chemical/tricalcium phosphate
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0021-9304
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
Copyright 2000 John Wiley & Sons, Inc.
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
54
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
129-38
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:11077412-Adsorption,
pubmed-meshheading:11077412-Animals,
pubmed-meshheading:11077412-Biocompatible Materials,
pubmed-meshheading:11077412-Bone Morphogenetic Protein 1,
pubmed-meshheading:11077412-Bone Morphogenetic Proteins,
pubmed-meshheading:11077412-Bone Substitutes,
pubmed-meshheading:11077412-Bone and Bones,
pubmed-meshheading:11077412-Calcium Phosphates,
pubmed-meshheading:11077412-Ceramics,
pubmed-meshheading:11077412-Durapatite,
pubmed-meshheading:11077412-Male,
pubmed-meshheading:11077412-Materials Testing,
pubmed-meshheading:11077412-Metalloendopeptidases,
pubmed-meshheading:11077412-Rats,
pubmed-meshheading:11077412-Rats, Wistar,
pubmed-meshheading:11077412-X-Ray Diffraction
|
|
pubmed:year |
2001
|
|
pubmed:articleTitle |
Comparative study of biphasic calcium phosphate ceramics impregnated with rhBMP-2 as bone substitutes.
|
|
pubmed:affiliation |
Oral Surgery, Department of Oral Restitution, Division of Oral Health Science, Tokyo Medical and Dental University Graduate School, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan. izumi.osur@tmd.ac.jp
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
