Linked Life Data

11077128

Source:http://linkedlifedata.com/resource/pubmed/id/11077128

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
2000-12-18
pubmed:abstractText
Female gender is considered to be a risk factor for ventricular arrhythmias. Furthermore, experimental studies have shown that estrogen has an impact on the electrophysiological properties of the heart. Thus, the effects of estrogen- (ERT) and progestin-estrogen- (PERT) replacement therapy on QT-interval length and dipersion as indicators of ventricular repolarisation have been examined in the present study. Twenty-two postmenopausal women without hormone replacement therapy and 16 postmenopausal women on ERT and 22 on PERT (age 48-71 years) were included. QT intervals were measured in five subsequent cycles of at least 10 leads of standard ECG. QT-dispersion was calculated as the difference between maximal and minimal QT-interval. QT-intervals and -dispersions were rate (QT(c)) and linear (QT(lc)) corrected. PERT significantly reduced ventricular QT-dispersion (QT-, QT(c)- and QT(lc)-dispersion) compared to the control group (QT(c)-dispersion (ms): 32+/-13 vs. 48+/-14; P<0.05), while ERT significantly prolonged QT-intervals (QT(c) mean (ms): 423+/-28 vs. 398+/-31; P<0.05) without affecting QT-dispersion. These findings support the hypothesis that sex hormones may directly modulate ventricular repolarisation in vivo. Above all, the progestin component of replacement therapy is suggested to homogenize spatial heterogeneity of ventricular repolarisation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0167-5273
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
75
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
161-5; discussion 165-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Effects of progestin-estrogen replacement therapy on QT-dispersion in postmenopausal women.
pubmed:affiliation
Institute of Clinical Pharmacology, Faculty of Clinical Medicine, Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1-3, D-68167, Mannheim, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't