Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2000-12-1
pubmed:abstractText
The kinetics of airway inflammation and remodeling processes following ovalbumin aerosol challenge in sensitized BALB/c mice was studied. Mice were exposed to either single or five ovalbumin challenges over 5 days. In both protocols, time-dependent increases in bronchoalveolar lavage (BAL) cellular fibronectin, neutrophils and eosinophils were observed. The kinetics of these events were similar in both protocols; however, the magnitude of the response was much greater following repeated challenges. BAL protein levels and lymphocyte numbers were increased only following repeated challenges, whereas interleukin (IL)-5 and IL-4 were increased in both protocols. Histological analysis revealed a time-dependent increase in epithelial cell proliferation and in mucus-producing epithelial cells. Proliferation of alveolar cells was observed only following repeated challenges. Airway hyperreactivity was observed in both protocols but was much greater following repeated challenges. Pretreatment with dexamethasone fully inhibited the inflammatory response and airway hyperreactivity but only partially inhibited the remodeling process. These data suggest that glucocorticoids, although potent anti-inflammatory agents, may not be potent in reducing the lung remodeling process associated with asthma.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1040-0605
pubmed:author
pubmed:issnType
Print
pubmed:volume
279
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
L1120-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:11076802-Animals, pubmed-meshheading:11076802-Anti-Inflammatory Agents, pubmed-meshheading:11076802-Asthma, pubmed-meshheading:11076802-Bronchial Hyperreactivity, pubmed-meshheading:11076802-Bronchoalveolar Lavage Fluid, pubmed-meshheading:11076802-Bronchoconstrictor Agents, pubmed-meshheading:11076802-Cell Division, pubmed-meshheading:11076802-Dexamethasone, pubmed-meshheading:11076802-Disease Models, Animal, pubmed-meshheading:11076802-Eosinophils, pubmed-meshheading:11076802-Epithelial Cells, pubmed-meshheading:11076802-Fibronectins, pubmed-meshheading:11076802-Immunoglobulin E, pubmed-meshheading:11076802-Interleukin-4, pubmed-meshheading:11076802-Interleukin-5, pubmed-meshheading:11076802-Leukocyte Count, pubmed-meshheading:11076802-Male, pubmed-meshheading:11076802-Methacholine Chloride, pubmed-meshheading:11076802-Mice, pubmed-meshheading:11076802-Mice, Inbred BALB C, pubmed-meshheading:11076802-Mice, Inbred C57BL, pubmed-meshheading:11076802-Mucus, pubmed-meshheading:11076802-Ovalbumin, pubmed-meshheading:11076802-Plasma, pubmed-meshheading:11076802-Pulmonary Alveoli, pubmed-meshheading:11076802-Respiratory Mucosa, pubmed-meshheading:11076802-Species Specificity, pubmed-meshheading:11076802-Time Factors
pubmed:year
2000
pubmed:articleTitle
Time course of inflammatory and remodeling events in a murine model of asthma: effect of steroid treatment.
pubmed:affiliation
Novartis Horsham Research Center, Horsham RH12 5AB, United Kingdom.
pubmed:publicationType
Journal Article, Comparative Study