Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2001-2-15
pubmed:abstractText
An allele association study of 19 polymorphisms in surfactant proteins SP-A1, SP-A2, SP-B, and SP-D genes in acute respiratory distress syndrome (ARDS) was carried out. Trend-test analysis revealed differences (p < 0.05) in the frequency of alleles for some of the microsatellite markers flanking SP-B, and for one polymorphism (C/T) at nucleotide 1580 [C/T (1580)], within codon 131 (Thr131Ile) of the SP-B gene. The latter determines the presence or absence of a potential N-linked glycosylation site. Multivariate analysis revealed significant differences only for the C/T (1580) polymorphism. When the ARDS population was divided into subgroups, idiopathic (i.e., pneumonia, etc.) or exogenic (i.e., trauma, etc.), significant differences were observed for the C/T (1580), for the idiopathic ARDS group, and the frequency of the C/C genotype was increased in this group. Based on the odds ratio, the C allele may be viewed as a susceptibility factor for ARDS. Although the expression of both C and T alleles occurs in heterozygous individuals, it is currently not known whether these alleles correspond to similar levels of SP-B protein. These data suggest that SP-B or a linked gene contributes to susceptibility to ARDS.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0009-9163
pubmed:author
pubmed:issnType
Print
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
181-91
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:11076040-Alleles, pubmed-meshheading:11076040-Amino Acid Substitution, pubmed-meshheading:11076040-Base Sequence, pubmed-meshheading:11076040-DNA Primers, pubmed-meshheading:11076040-Exons, pubmed-meshheading:11076040-Gene Frequency, pubmed-meshheading:11076040-Genotype, pubmed-meshheading:11076040-Germany, pubmed-meshheading:11076040-Glycoproteins, pubmed-meshheading:11076040-Humans, pubmed-meshheading:11076040-Infant, Newborn, pubmed-meshheading:11076040-Logistic Models, pubmed-meshheading:11076040-Lung, pubmed-meshheading:11076040-Microsatellite Repeats, pubmed-meshheading:11076040-Polymorphism, Genetic, pubmed-meshheading:11076040-Proteolipids, pubmed-meshheading:11076040-Pulmonary Surfactant-Associated Protein A, pubmed-meshheading:11076040-Pulmonary Surfactant-Associated Protein D, pubmed-meshheading:11076040-Pulmonary Surfactant-Associated Proteins, pubmed-meshheading:11076040-Pulmonary Surfactants, pubmed-meshheading:11076040-Respiratory Distress Syndrome, Newborn
pubmed:year
2000
pubmed:articleTitle
Polymorphisms of human SP-A, SP-B, and SP-D genes: association of SP-B Thr131Ile with ARDS.
pubmed:affiliation
Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey 17033, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't