Linked Life Data

11074302

Source:http://linkedlifedata.com/resource/pubmed/id/11074302

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-3
pubmed:dateCreated
2000-12-7
pubmed:abstractText
The association between alcohol consumption and esophageal cancer is particularly marked in Northern France where an apple brandy, Calvados, is drunk. Calvados contains branched chain alcohols such as isoamyl alcohol (IAA) and it has been suggested that these play a particular role in the etiology of the cancer. In this study the effect of IAA, alone or with ethanol, on the ethylation of DNA by N-nitrosodiethylamine was evaluated in living rats, and the effect of IAA on the metabolism of N-nitrosodiethylamine by rat liver microsomes or esophageal epithelium was measured. As previously reported co-administration of ethanol increases the ethylation of esophageal DNA by the nitrosamine by almost 2-fold, but IAA did not alter the proportion of DNA ethylation between liver and esophagus. When both alcohols were given together with the nitrosamine, the alteration on DNA ethylation produced by ethanol remained unchanged. Different from ethanol, IAA inhibited NDEA metabolism catalyzed not only by rat liver microsomes (K(i)=0.42 mM), but also by esophageal epithelium (K(i)=0.52 mM), thus possessing an affinity also for the esophageal NDEA metabolizing P450.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0300-483X
pubmed:author
pubmed:issnType
Print
pubmed:day
26
pubmed:volume
151
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
73-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Differences between isoamyl alcohol and ethanol on the metabolism and DNA ethylation of N-nitrosodiethylamine in the rat.
pubmed:affiliation
Departmento de Bioquímica, IBRAG, Universidade do Estado do Rio de Janeiro, Av. 28 de Setembro, 87, fundos 4 andar, Vila Isabel, 20551-013, Rio de Janeiro, Brazil. fpinto@uerj.br
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't