Source:http://linkedlifedata.com/resource/pubmed/id/11074014
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2000-11-21
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pubmed:abstractText |
Quantitative trait locus (QTL) mapping was used to locate genes that determine the difference in cholesterol gallstone disease between the gallstone-susceptible strain C57L/J and the gallstone-resistant strain AKR/J. Gallstone weight was determined in 231 male (AKR x C57L) F(1) x AKR backcross mice fed a lithogenic diet containing 1% cholesterol, 0.5% cholic acid, and 15% butterfat for 8 wk. Mice having no stones and mice having the largest stones were genotyped at approximately 20-cM intervals to find the loci determining cholesterol gallstone formation. The major locus, Lith1, mapped near D2Mit56 and was confirmed by constructing a congenic strain, AK. L-Lith1(s). Another locus, Lith2, mapped near D19Mit58 and was also confirmed by constructing a congenic strain AK.L-Lith2(s). Other suggestive, but not statistically significant, loci mapped to chromosomes 6, 7, 8, 10, and X. The identification of these Lith genes will elucidate the pathophysiology of cholesterol gallstone formation.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1531-2267
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:day |
9
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
59-65
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11074014-Animals,
pubmed-meshheading:11074014-Cholelithiasis,
pubmed-meshheading:11074014-Cholesterol,
pubmed-meshheading:11074014-Cholesterol, Dietary,
pubmed-meshheading:11074014-Chromosome Mapping,
pubmed-meshheading:11074014-Crosses, Genetic,
pubmed-meshheading:11074014-Gallbladder,
pubmed-meshheading:11074014-Genetic Markers,
pubmed-meshheading:11074014-Genetic Predisposition to Disease,
pubmed-meshheading:11074014-Male,
pubmed-meshheading:11074014-Mice,
pubmed-meshheading:11074014-Mice, Inbred AKR,
pubmed-meshheading:11074014-Mice, Inbred C57BL,
pubmed-meshheading:11074014-Organ Size,
pubmed-meshheading:11074014-Quantitative Trait, Heritable
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pubmed:year |
2000
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pubmed:articleTitle |
Quantitative trait loci mapping for cholesterol gallstones in AKR/J and C57L/J strains of mice.
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pubmed:affiliation |
The Jackson Laboratory, Bar Harbor, Maine 04609, USA. bjp@jax.org
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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