Linked Life Data

11073068

Source:http://linkedlifedata.com/resource/pubmed/id/11073068

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2001-2-7
pubmed:abstractText
The effect of a loss of occlusal stimuli upon the distribution and structure of the periodontal mechanoreceptors of the rat mandibular molar was examined after extracting opposing molars. The hypofunctional periodontal ligament narrowed significantly two weeks after tooth extraction, associated with an altered morphology of the Ruffini endings that showed typical dendritic profiles in normal controls. At four weeks and later periods after extraction, the Ruffini endings-including those without light microscopic changes demonstrated unusual ultrastructural features such as the eccentric localization of mitochondria along the axonal membrane and loss of other cell organelles, unusual elongation of axonal microprojections, or a deep invagination of the Schwann sheath into the axoplasm. Immunoreactivity for the growth-associated protein-43 (GAP-43) in the Ruffini endings was restricted to the Schwann element in both the normal and hypofunctional periodontal ligament, but the reaction was weaker and even negligible in some cases in the latter ligament. The present results suggest that occlusal stimuli are essential for maintaining the structural integrity of the periodontal ligament, including that of periodontal mechanoreceptors. A decreased immunoreactivity for GAP-43 in the Schwann sheaths supports the notion of a possible functional alteration in the Ruffini endings that showed no structural abnormality.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0914-9465
pubmed:author
pubmed:issnType
Print
pubmed:volume
63
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
369-80
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Time-related changes in periodontal mechanoreceptors in rat molars after the loss of occlusal stimuli.
pubmed:affiliation
First Department of Orthodontics, Faculty of Dentistry, Tokyo Medical and Dental University, Yushima, Japan. muraort1@dent.tmd.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't