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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2000-12-4
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pubmed:abstractText |
The genomic sequence of the human GCMa/GCM1 gene, a mammalian homologue of Drosophila melanogaster GCM, was determined. Drosophila GCM is a neural transcription factor that regulates glial cell fate. The mammalian homolog however, is a placenta-specific transcription factor that is necessary for placental development. The 22 kb DNA sequence spanning the GCMa gene contains six exons and five introns, encoding a 2.8 kb cDNA. Overall genomic organization is similar for the human and mouse. Several potential binding sites for transcription factors like GATA, Oct-1, and bHLH proteins were found in the 5'-flanking region of the human gene. A DNA motif for GCM protein binding exists in the 5'-flanking region that is highly homologous with that of the mouse gene. The location of this gene was mapped to chromosome 6 using fluorescence in situ hybridization.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Basic Helix-Loop-Helix...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/GATA2 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/GATA2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/GATA3 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/GATA3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/GCM1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Gata2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Gata3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Gcm1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/HCFC1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Hcfc1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Host Cell Factor C1,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Octamer Transcription Factor-1,
http://linkedlifedata.com/resource/pubmed/chemical/POU2F1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Pou2f1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2000 Academic Press.
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pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
278
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
134-9
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pubmed:dateRevised |
2006-11-28
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pubmed:meshHeading |
pubmed-meshheading:11071865-Animals,
pubmed-meshheading:11071865-Base Sequence,
pubmed-meshheading:11071865-Basic Helix-Loop-Helix Transcription Factors,
pubmed-meshheading:11071865-Binding Sites,
pubmed-meshheading:11071865-Chromosome Mapping,
pubmed-meshheading:11071865-Chromosomes, Human, Pair 6,
pubmed-meshheading:11071865-DNA, Complementary,
pubmed-meshheading:11071865-DNA-Binding Proteins,
pubmed-meshheading:11071865-Exons,
pubmed-meshheading:11071865-GATA2 Transcription Factor,
pubmed-meshheading:11071865-GATA3 Transcription Factor,
pubmed-meshheading:11071865-Gene Library,
pubmed-meshheading:11071865-Host Cell Factor C1,
pubmed-meshheading:11071865-Humans,
pubmed-meshheading:11071865-In Situ Hybridization, Fluorescence,
pubmed-meshheading:11071865-Introns,
pubmed-meshheading:11071865-Mice,
pubmed-meshheading:11071865-Models, Genetic,
pubmed-meshheading:11071865-Molecular Sequence Data,
pubmed-meshheading:11071865-Neuropeptides,
pubmed-meshheading:11071865-Nuclear Proteins,
pubmed-meshheading:11071865-Octamer Transcription Factor-1,
pubmed-meshheading:11071865-Placenta,
pubmed-meshheading:11071865-Polymerase Chain Reaction,
pubmed-meshheading:11071865-Sequence Homology, Nucleic Acid,
pubmed-meshheading:11071865-Trans-Activators,
pubmed-meshheading:11071865-Transcription Factors,
pubmed-meshheading:11071865-Trophoblasts
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pubmed:year |
2000
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pubmed:articleTitle |
Genomic organization, chromosomal localization, and the complete 22 kb DNA sequence of the human GCMa/GCM1, a placenta-specific transcription factor gene.
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pubmed:affiliation |
Institute for Comprehensive Medical Science, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan. kyamada@fujita-hu.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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