| pubmed-article:11070172 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11070172 | lifeskim:mentions | umls-concept:C0330390 | lld:lifeskim |
| pubmed-article:11070172 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:11070172 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:11070172 | lifeskim:mentions | umls-concept:C1155328 | lld:lifeskim |
| pubmed-article:11070172 | lifeskim:mentions | umls-concept:C1415900 | lld:lifeskim |
| pubmed-article:11070172 | lifeskim:mentions | umls-concept:C0920532 | lld:lifeskim |
| pubmed-article:11070172 | lifeskim:mentions | umls-concept:C0205224 | lld:lifeskim |
| pubmed-article:11070172 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:11070172 | pubmed:dateCreated | 2000-11-8 | lld:pubmed |
| pubmed-article:11070172 | pubmed:abstractText | Induction of the interferon (IFN)-alpha/beta gene transcription in virus-infected cells is an event central to innate immunity. Mice lacking the transcription factor IRF-3 are more vulnerable to virus infection. In embryonic fibroblasts, virus-induced IFN-alpha/beta gene expression levels are reduced and the spectrum of the IFN-alpha mRNA subspecies altered. Furthermore, cells additionally defective in IRF-7 expression totally fail to induce these genes in response to infections by any of the virus types tested. In these cells, a normal profile of IFN-alpha/beta mRNA induction can be achieved by coexpressing both IRF-3 and IRF-7. These results demonstrate the essential and distinct roles of thetwo factors, which together ensure the transcriptional efficiency and diversity of IFN-alpha/beta genes for the antiviral response. | lld:pubmed |
| pubmed-article:11070172 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11070172 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11070172 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11070172 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:11070172 | pubmed:issn | 1074-7613 | lld:pubmed |
| pubmed-article:11070172 | pubmed:author | pubmed-author:TanakaNN | lld:pubmed |
| pubmed-article:11070172 | pubmed:author | pubmed-author:SatoMM | lld:pubmed |
| pubmed-article:11070172 | pubmed:author | pubmed-author:NakaiMM | lld:pubmed |
| pubmed-article:11070172 | pubmed:author | pubmed-author:TaniguchiTT | lld:pubmed |
| pubmed-article:11070172 | pubmed:author | pubmed-author:NoguchiSS | lld:pubmed |
| pubmed-article:11070172 | pubmed:author | pubmed-author:NakayaTT | lld:pubmed |
| pubmed-article:11070172 | pubmed:author | pubmed-author:HataNN | lld:pubmed |
| pubmed-article:11070172 | pubmed:author | pubmed-author:KatsukiMM | lld:pubmed |
| pubmed-article:11070172 | pubmed:author | pubmed-author:OgasawaraKK | lld:pubmed |
| pubmed-article:11070172 | pubmed:author | pubmed-author:SuemoriHH | lld:pubmed |
| pubmed-article:11070172 | pubmed:author | pubmed-author:AsagiriMM | lld:pubmed |
| pubmed-article:11070172 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11070172 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:11070172 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11070172 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11070172 | pubmed:pagination | 539-48 | lld:pubmed |
| pubmed-article:11070172 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:11070172 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11070172 | pubmed:articleTitle | Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction. | lld:pubmed |
| pubmed-article:11070172 | pubmed:affiliation | Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Japan. | lld:pubmed |
| pubmed-article:11070172 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11070172 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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