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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2000-11-8
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pubmed:abstractText |
Induction of the interferon (IFN)-alpha/beta gene transcription in virus-infected cells is an event central to innate immunity. Mice lacking the transcription factor IRF-3 are more vulnerable to virus infection. In embryonic fibroblasts, virus-induced IFN-alpha/beta gene expression levels are reduced and the spectrum of the IFN-alpha mRNA subspecies altered. Furthermore, cells additionally defective in IRF-7 expression totally fail to induce these genes in response to infections by any of the virus types tested. In these cells, a normal profile of IFN-alpha/beta mRNA induction can be achieved by coexpressing both IRF-3 and IRF-7. These results demonstrate the essential and distinct roles of thetwo factors, which together ensure the transcriptional efficiency and diversity of IFN-alpha/beta genes for the antiviral response.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon Regulatory Factor-3,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon Regulatory Factor-7,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon Type I,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-beta,
http://linkedlifedata.com/resource/pubmed/chemical/Irf3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Irf7 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1074-7613
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pubmed:author |
pubmed-author:AsagiriMM,
pubmed-author:HataNN,
pubmed-author:KatsukiMM,
pubmed-author:NakaiMM,
pubmed-author:NakayaTT,
pubmed-author:NoguchiSS,
pubmed-author:OgasawaraKK,
pubmed-author:SatoMM,
pubmed-author:SuemoriHH,
pubmed-author:TanakaNN,
pubmed-author:TaniguchiTT
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pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
539-48
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11070172-Animals,
pubmed-meshheading:11070172-DNA-Binding Proteins,
pubmed-meshheading:11070172-Down-Regulation,
pubmed-meshheading:11070172-Embryo, Mammalian,
pubmed-meshheading:11070172-Female,
pubmed-meshheading:11070172-Fibroblasts,
pubmed-meshheading:11070172-Gene Expression Regulation,
pubmed-meshheading:11070172-Gene Targeting,
pubmed-meshheading:11070172-Interferon Regulatory Factor-3,
pubmed-meshheading:11070172-Interferon Regulatory Factor-7,
pubmed-meshheading:11070172-Interferon Type I,
pubmed-meshheading:11070172-Interferon-beta,
pubmed-meshheading:11070172-Male,
pubmed-meshheading:11070172-Mice,
pubmed-meshheading:11070172-Mice, Inbred C57BL,
pubmed-meshheading:11070172-Mice, Knockout,
pubmed-meshheading:11070172-Mice, Transgenic,
pubmed-meshheading:11070172-Newcastle disease virus,
pubmed-meshheading:11070172-Promoter Regions, Genetic,
pubmed-meshheading:11070172-RNA, Messenger,
pubmed-meshheading:11070172-Retroviridae,
pubmed-meshheading:11070172-Signal Transduction,
pubmed-meshheading:11070172-Transcription Factors,
pubmed-meshheading:11070172-Transcriptional Activation
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pubmed:year |
2000
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pubmed:articleTitle |
Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction.
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pubmed:affiliation |
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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