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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2000-11-8
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pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ275352,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ275353,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ275354,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ275355,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ275356,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ275357,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ275358,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ275359,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ275360,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ275361,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ275362,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ275363,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ275364,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ275365,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ275366,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ275367,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ275368,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ275369,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ275370,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ275371,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ275372,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ275373,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ275374,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ275375,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ275376,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ275377,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ275378,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ275379,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ275380,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ275381
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pubmed:abstractText |
Infection of humans with Epstein-Barr virus (EBV) may cause infectious mononucleosis (IM). Analysis of single EBV-infected cells from tonsils of IM patients for rearranged immunoglobulin genes revealed two strategies of EBV for rapid and massive spread in the B cell compartment: the direct infection of many naive as well as memory and/or germinal center B cells and the expansion of the latter cells to large clones. In IM, the generation of virus-harboring memory B cells from naive B cells passing through a germinal center reaction likely plays no role. Members of clones can show distinct morphologies and likely also EBV gene expression patterns, and this ability implies a mechanism by which EBV-harboring cells can evade immune surveillance and establish a pool of persisting EBV-infected B cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1074-7613
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
485-95
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11070167-Adolescent,
pubmed-meshheading:11070167-Adult,
pubmed-meshheading:11070167-B-Lymphocyte Subsets,
pubmed-meshheading:11070167-Cell Differentiation,
pubmed-meshheading:11070167-Clone Cells,
pubmed-meshheading:11070167-Female,
pubmed-meshheading:11070167-Gene Expression Regulation, Viral,
pubmed-meshheading:11070167-Gene Rearrangement, B-Lymphocyte,
pubmed-meshheading:11070167-Genetic Variation,
pubmed-meshheading:11070167-Germinal Center,
pubmed-meshheading:11070167-Herpesvirus 4, Human,
pubmed-meshheading:11070167-Hodgkin Disease,
pubmed-meshheading:11070167-Humans,
pubmed-meshheading:11070167-Immunologic Memory,
pubmed-meshheading:11070167-Immunophenotyping,
pubmed-meshheading:11070167-Infectious Mononucleosis,
pubmed-meshheading:11070167-Interphase,
pubmed-meshheading:11070167-Male,
pubmed-meshheading:11070167-Molecular Sequence Data,
pubmed-meshheading:11070167-Organ Specificity,
pubmed-meshheading:11070167-Palatine Tonsil,
pubmed-meshheading:11070167-Polymerase Chain Reaction,
pubmed-meshheading:11070167-Reed-Sternberg Cells,
pubmed-meshheading:11070167-Virus Latency,
pubmed-meshheading:11070167-Virus Replication
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pubmed:year |
2000
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pubmed:articleTitle |
EBV-infected B cells in infectious mononucleosis: viral strategies for spreading in the B cell compartment and establishing latency.
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pubmed:affiliation |
Institute for Genetics and Department of Internal Medicine I, University of Cologne, Germany. jkurth@mac.genetik.uni-koeln.de
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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