Source:http://linkedlifedata.com/resource/pubmed/id/11069839
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
2000-12-4
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pubmed:abstractText |
Destruction of subepithelial basement membrane is a key event in the pathogenesis of idiopathic pulmonary fibrosis (IPF). To evaluate the role of matrix metalloproteinases (MMPs) in parenchymal remodeling in idiopathic interstitial pneumonia (IIP), we studied MMP-2 and -9 activity, in bronchoalveolar lavage fluid (BALF) by zymography and the expression of MMP-2 and -9 and TIMP-2 in lung tissue by immunohistochemistry. BALF and lung tissues were collected from 26 patients with usual interstitial pneumonia (IPF-UIP), 11 with nonspecific interstitial pneumonia (NSIP), and 6 with bronchiolitis obliterans organizing pneumonia (BOOP). IPF-UIP cases showed predominant expression of MMP-9, whereas NSIP and BOOP cases showed predominant MMP-2 expression in BALF and in tissues. In BALF samples from rapidly progressive IPF-UIP cases, neutrophil-derived MMP-9 activity, as well as MMP-9 active form were characteristically detected. Furthermore, the MMP-9 activity correlated significantly with an increase of neutrophils in BALF, whereas the MMP-2 activity associated with NSIP and BOOP correlated with an increase of lymphocytes. These results indicate that MMP-9 in IPF-UIP and MMP-2 in NSIP and BOOP may contribute to pulmonary structural remodeling through type IV collagenolytic activity. The characteristic contributions of matrix-degrading proteins may relate to the distinct prognostic features of these diseases.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 9,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinases,
http://linkedlifedata.com/resource/pubmed/chemical/Tissue Inhibitor of...
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1073-449X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
162
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1949-56
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11069839-Adult,
pubmed-meshheading:11069839-Aged,
pubmed-meshheading:11069839-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:11069839-Cryptogenic Organizing Pneumonia,
pubmed-meshheading:11069839-Female,
pubmed-meshheading:11069839-Humans,
pubmed-meshheading:11069839-Immunohistochemistry,
pubmed-meshheading:11069839-Lung,
pubmed-meshheading:11069839-Lung Diseases, Interstitial,
pubmed-meshheading:11069839-Male,
pubmed-meshheading:11069839-Matrix Metalloproteinase 2,
pubmed-meshheading:11069839-Matrix Metalloproteinase 9,
pubmed-meshheading:11069839-Matrix Metalloproteinases,
pubmed-meshheading:11069839-Middle Aged,
pubmed-meshheading:11069839-Tissue Inhibitor of Metalloproteinase-2
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pubmed:year |
2000
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pubmed:articleTitle |
Characteristic elevation of matrix metalloproteinase activity in idiopathic interstitial pneumonias.
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pubmed:affiliation |
First Department of Internal Medicine and Department of Microbiology, Kumamoto University School of Medicine, Kumamoto, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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