| pubmed-article:11069838 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11069838 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:11069838 | lifeskim:mentions | umls-concept:C0450127 | lld:lifeskim |
| pubmed-article:11069838 | lifeskim:mentions | umls-concept:C0458827 | lld:lifeskim |
| pubmed-article:11069838 | lifeskim:mentions | umls-concept:C0072978 | lld:lifeskim |
| pubmed-article:11069838 | lifeskim:mentions | umls-concept:C0032214 | lld:lifeskim |
| pubmed-article:11069838 | lifeskim:mentions | umls-concept:C0600138 | lld:lifeskim |
| pubmed-article:11069838 | lifeskim:mentions | umls-concept:C0015219 | lld:lifeskim |
| pubmed-article:11069838 | lifeskim:mentions | umls-concept:C0332465 | lld:lifeskim |
| pubmed-article:11069838 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:11069838 | pubmed:dateCreated | 2000-12-4 | lld:pubmed |
| pubmed-article:11069838 | pubmed:abstractText | Although lung transplantation is a widely applied therapeutic modality for end-stage pulmonary disease, the long-term survival following this procedure is limited by the development of bronchiolitis obliterans (BO). We investigated the role of RANTES, a C-C chemokine, in the evolution of fibrous airway obliteration (FAO) using a rat heterotopic tracheal transplant model. RANTES was highly expressed in infiltrating mononuclear cells in both allogeneic and isogeneic grafts as revealed by immunohistochemistry. Using a miniosmotic pump, neutralizing anti-RANTES antibody was locally and continuously infused to allografts, whereas recombinant rat RANTES was administered to isografts. Anti-RANTES antibody treatment decreased the number of CD4(+) infiltrating cells in allotracheas and preserved luminal patency compared with those of allocontrols. However, RANTES infusion in isografts did not induce FAO, even though CD4(+) cell migration was increased by this treatment. It appears that RANTES is relevant to the recruitment of CD4(+) cells and the development of FAO in the process of allorejection. Local administration of anti-RANTES might be a therapeutic option for BO following lung transplantation. | lld:pubmed |
| pubmed-article:11069838 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11069838 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11069838 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:11069838 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11069838 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11069838 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11069838 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11069838 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:11069838 | pubmed:issn | 1073-449X | lld:pubmed |
| pubmed-article:11069838 | pubmed:author | pubmed-author:FischerSS | lld:pubmed |
| pubmed-article:11069838 | pubmed:author | pubmed-author:LinDD | lld:pubmed |
| pubmed-article:11069838 | pubmed:author | pubmed-author:SugaMM | lld:pubmed |
| pubmed-article:11069838 | pubmed:author | pubmed-author:MacleanA AAA | lld:pubmed |
| pubmed-article:11069838 | pubmed:author | pubmed-author:KeshavjeeSS | lld:pubmed |
| pubmed-article:11069838 | pubmed:author | pubmed-author:MoreiraJ MJM | lld:pubmed |
| pubmed-article:11069838 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11069838 | pubmed:volume | 162 | lld:pubmed |
| pubmed-article:11069838 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11069838 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11069838 | pubmed:pagination | 1940-8 | lld:pubmed |
| pubmed-article:11069838 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:11069838 | pubmed:meshHeading | pubmed-meshheading:11069838... | lld:pubmed |
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| pubmed-article:11069838 | pubmed:meshHeading | pubmed-meshheading:11069838... | lld:pubmed |
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| pubmed-article:11069838 | pubmed:meshHeading | pubmed-meshheading:11069838... | lld:pubmed |
| pubmed-article:11069838 | pubmed:meshHeading | pubmed-meshheading:11069838... | lld:pubmed |
| pubmed-article:11069838 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11069838 | pubmed:articleTitle | RANTES plays an important role in the evolution of allograft transplant-induced fibrous airway obliteration. | lld:pubmed |
| pubmed-article:11069838 | pubmed:affiliation | Thoracic Surgery Research Laboratory, Toronto General Hospital Research Institute, and Department of Surgery, University of Toronto, Toronto, Ontario, Canada. | lld:pubmed |
| pubmed-article:11069838 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11069838 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:81780 | entrezgene:pubmed | pubmed-article:11069838 | lld:entrezgene |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11069838 | lld:pubmed |
