Linked Life Data

11068705

Source:http://linkedlifedata.com/resource/pubmed/id/11068705

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2001-2-7
pubmed:abstractText
We investigated the effects of dietary docosahexaenoic acid (DHA, 22:6 n-3) and phosphatidylcholine (PC) on maze behavior and brain fatty acids in mice. Male Crj:CD-1 mice (3 wk old) were fed a diet containing 2% DHA and 3% palm oil (DHA group); 5% PC (PC group); 1% DHA, 2.5% PC and 1.5% palm oil (DHA + PC group); 5% palm oil (Palm oil control group) or MF laboratory chow (MF control group) for 7 mo. After this time maze-learning ability was assessed. The time required to reach the maze exit and the number of times that a mouse strayed into blind alleys in the maze were measured three times every four days. After the last learning test, all mice were sacrificed and plasma and brain were analyzed for fatty acid composition. The DHA and PC groups required less time to reach the maze exit and strayed less into blind alleys than the control group in the third trial. The difference between the DHA or PC groups and control mice was statistically significant (p < 0.05). In the total lipids of plasma and brain of mice fed DHA, there was a significant increase in DHA levels and a concomitant decrease in arachidonic acid (AA, 20:4 n-6). Similar changes in fatty acid composition were observed in brain phosphatidylcholine and phosphatidylethanolamine for this group of mice. However, this pattern of changes in brain fatty acids was not evident in the PC group. Our data suggest that maze-learning ability in mice is enhanced by intakes of DHA and PC. However, the mechanisms by which the DHA and PC diets improved learning ability appear to be different. A synergistic effect of DHA and PC on learning ability is not apparent in the DHA + PC group.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0300-9831
pubmed:author
pubmed:issnType
Print
pubmed:volume
70
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
251-9
pubmed:dateRevised
2007-2-21
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Effect of dietary docosahexaenoic acid and phosphatidylcholine on maze behavior and fatty acid composition of plasma and brain lipids in mice.
pubmed:affiliation
National Food Research Institute, Kannondai, Tsukuba, Ibaraki, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't