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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2000-12-18
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pubmed:abstractText |
Central administration of amylin (2.2 microg/rat, i.c.v.) reduces (from a minimum of 67% to 83%) indomethacin (Indo, 20 mg Kg(-1), orally) induced ulcers in rats. The anti-ulcer effect of the peptide is not removed by the administration of prokinetic drugs like domperidone or neostigmine but it is reduced by 35% in rats treated with capsaicin or with the CGRP antagonist, CGRP(8-37). These data indicate that amylin gastroprotection involves capsaicin-sensitive nerve fiber leading to CGRP-dependent gastric vasodilatory effect. Additional mechanisms could involve noradrenergic alpha(2) receptors as the peptide gastroprotective activity is reduced from 67% to 20% by the alpha(2) antagonist yohimbine.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Amyloid,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Ulcer Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Calcitonin Gene-Related Peptide,
http://linkedlifedata.com/resource/pubmed/chemical/Capsaicin,
http://linkedlifedata.com/resource/pubmed/chemical/Domperidone,
http://linkedlifedata.com/resource/pubmed/chemical/Indomethacin,
http://linkedlifedata.com/resource/pubmed/chemical/Islet Amyloid Polypeptide,
http://linkedlifedata.com/resource/pubmed/chemical/Neostigmine,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Yohimbine,
http://linkedlifedata.com/resource/pubmed/chemical/calcitonin gene-related peptide...
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0196-9781
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1537-41
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:11068101-Adrenergic alpha-Antagonists,
pubmed-meshheading:11068101-Amyloid,
pubmed-meshheading:11068101-Animals,
pubmed-meshheading:11068101-Anti-Ulcer Agents,
pubmed-meshheading:11068101-Calcitonin Gene-Related Peptide,
pubmed-meshheading:11068101-Capsaicin,
pubmed-meshheading:11068101-Domperidone,
pubmed-meshheading:11068101-Indomethacin,
pubmed-meshheading:11068101-Islet Amyloid Polypeptide,
pubmed-meshheading:11068101-Male,
pubmed-meshheading:11068101-Neostigmine,
pubmed-meshheading:11068101-Neurons, Afferent,
pubmed-meshheading:11068101-Peptide Fragments,
pubmed-meshheading:11068101-Rats,
pubmed-meshheading:11068101-Rats, Sprague-Dawley,
pubmed-meshheading:11068101-Stomach Ulcer,
pubmed-meshheading:11068101-Yohimbine
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pubmed:year |
2000
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pubmed:articleTitle |
The role of sensory neurons in the antiulcer effect of centrally injected amylin in rat.
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pubmed:affiliation |
Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Via Vanvitelli 32, 20129, Milano, Italy. guidobon@mailserver.unimi.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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