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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2000-11-21
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pubmed:abstractText |
In patients with active systemic lupus erythematosus (SLE), a marked B lymphocytopenia was identified that affected CD19(+)/CD27(-) naive B cells more than CD19(+)/CD27(+) memory B cells, leading to a relative predominance of CD27-expressing peripheral B cells. CD27(high)/CD38(+)/CD19(dim)/surface Ig(low)/CD20(-)/CD138(+) plasma cells were found at high frequencies in active but not inactive SLE patients. Upon immunosuppressive therapy, CD27(high) plasma cells and naive CD27(-) B cells were markedly decreased in the peripheral blood. Mutational analysis of V gene rearrangements of individual B cells confirmed that CD27(+) B cells coexpressing IgD were memory B cells preferentially using V(H)3 family members with multiple somatic mutations. CD27(high) plasma cells showed a similar degree of somatic hypermutation, but preferentially employed V(H)4 family members. These results indicate that there are profound abnormalities in the various B cell compartments in SLE that respond differently to immunosuppressive therapy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ADP-ribosyl Cyclase,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD19,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD27,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD38,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD95,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/CD38 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DR Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin Heavy Chains,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin Variable Region,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulins,
http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/NAD Nucleosidase,
http://linkedlifedata.com/resource/pubmed/chemical/Proteoglycans,
http://linkedlifedata.com/resource/pubmed/chemical/SDC1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Syndecan-1,
http://linkedlifedata.com/resource/pubmed/chemical/Syndecans
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
165
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5970-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11067960-ADP-ribosyl Cyclase,
pubmed-meshheading:11067960-Adolescent,
pubmed-meshheading:11067960-Adult,
pubmed-meshheading:11067960-Aged,
pubmed-meshheading:11067960-Antigens, CD,
pubmed-meshheading:11067960-Antigens, CD19,
pubmed-meshheading:11067960-Antigens, CD27,
pubmed-meshheading:11067960-Antigens, CD38,
pubmed-meshheading:11067960-Antigens, CD95,
pubmed-meshheading:11067960-Antigens, Differentiation,
pubmed-meshheading:11067960-B-Lymphocyte Subsets,
pubmed-meshheading:11067960-Base Sequence,
pubmed-meshheading:11067960-Female,
pubmed-meshheading:11067960-Gene Rearrangement, B-Lymphocyte, Heavy Chain,
pubmed-meshheading:11067960-HLA-DR Antigens,
pubmed-meshheading:11067960-Homeostasis,
pubmed-meshheading:11067960-Humans,
pubmed-meshheading:11067960-Immunoglobulin Heavy Chains,
pubmed-meshheading:11067960-Immunoglobulin Variable Region,
pubmed-meshheading:11067960-Immunoglobulins,
pubmed-meshheading:11067960-Immunologic Memory,
pubmed-meshheading:11067960-Immunophenotyping,
pubmed-meshheading:11067960-Immunosuppressive Agents,
pubmed-meshheading:11067960-Interphase,
pubmed-meshheading:11067960-Intracellular Fluid,
pubmed-meshheading:11067960-Lupus Erythematosus, Systemic,
pubmed-meshheading:11067960-Lymphocyte Count,
pubmed-meshheading:11067960-Lymphopenia,
pubmed-meshheading:11067960-Male,
pubmed-meshheading:11067960-Membrane Glycoproteins,
pubmed-meshheading:11067960-Middle Aged,
pubmed-meshheading:11067960-Molecular Sequence Data,
pubmed-meshheading:11067960-Mutation,
pubmed-meshheading:11067960-NAD+ Nucleosidase,
pubmed-meshheading:11067960-Proteoglycans,
pubmed-meshheading:11067960-Syndecan-1,
pubmed-meshheading:11067960-Syndecans
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pubmed:year |
2000
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pubmed:articleTitle |
Disturbed peripheral B lymphocyte homeostasis in systemic lupus erythematosus.
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pubmed:affiliation |
Deutsches Rheuma-Forschungszentrum Berlin, Charite University Hospital, Berlin, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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