Source:http://linkedlifedata.com/resource/pubmed/id/11064622
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2000-11-9
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pubmed:abstractText |
No pharmacokinetic data are available with respect to the plasma concentrations and fentanyl or sufentanil during epidural administration in children. This double-blind randomized study included 12 children (5-12 yr). Patients in group F were given an epidural loading dose of fentanyl 1.5 micrograms kg-1 and in group S sufentanil 0.6 microgram kg-1. Both groups then received a continuous epidural infusion of bupivacaine 5 mg kg-1 day-1 with either fentanyl 5 micrograms kg-1 day-1 or sufentanil 2 micrograms kg-1 day-1. An epidural PCA system was also given to the children (bolus: bupivacaine 0.2 mg kg-1 and fentanyl 0.2 microgram kg-1 or sufentanil 0.08 microgram kg-1). Maximal median concentrations of plasma (0.117-0.247 ng ml-1 for fentanyl and 0.027-0.074 ng ml-1 for sufentanil) were reached approximately 30 and 20 min respectively after the loading doses. These values were similar to those measured after 48 h.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Analgesics, Opioid,
http://linkedlifedata.com/resource/pubmed/chemical/Anesthetics, Local,
http://linkedlifedata.com/resource/pubmed/chemical/Bupivacaine,
http://linkedlifedata.com/resource/pubmed/chemical/Fentanyl,
http://linkedlifedata.com/resource/pubmed/chemical/Sufentanil
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0007-0912
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
85
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
615-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11064622-Analgesia, Epidural,
pubmed-meshheading:11064622-Analgesia, Patient-Controlled,
pubmed-meshheading:11064622-Analgesics, Opioid,
pubmed-meshheading:11064622-Anesthetics, Local,
pubmed-meshheading:11064622-Bupivacaine,
pubmed-meshheading:11064622-Child,
pubmed-meshheading:11064622-Child, Preschool,
pubmed-meshheading:11064622-Double-Blind Method,
pubmed-meshheading:11064622-Fentanyl,
pubmed-meshheading:11064622-Humans,
pubmed-meshheading:11064622-Pain, Postoperative,
pubmed-meshheading:11064622-Prospective Studies,
pubmed-meshheading:11064622-Sufentanil
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pubmed:year |
2000
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pubmed:articleTitle |
Fentanyl versus sufentanil: plasma concentrations during continuous epidural postoperative infusion in children.
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pubmed:affiliation |
Department of Anaesthesiology, Hôtel-Dieu, CHR Nantes, France.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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