Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2000-11-21
pubmed:abstractText
Intraflagellar transport (IFT) is a rapid movement of multi-subunit protein particles along flagellar microtubules and is required for assembly and maintenance of eukaryotic flagella. We cloned and sequenced a Chlamydomonas cDNA encoding the IFT88 subunit of the IFT particle and identified a Chlamydomonas insertional mutant that is missing this gene. The phenotype of this mutant is normal except for the complete absence of flagella. IFT88 is homologous to mouse and human genes called Tg737. Mice with defects in Tg737 die shortly after birth from polycystic kidney disease. We show that the primary cilia in the kidney of Tg737 mutant mice are shorter than normal. This indicates that IFT is important for primary cilia assembly in mammals. It is likely that primary cilia have an important function in the kidney and that defects in their assembly can lead to polycystic kidney disease.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-10069812, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-10199624, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-10220415, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-10227290, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-10330409, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-10517637, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-10517638, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-10517866, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-10545491, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-10545497, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-10548469, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-10577904, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-10722883, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-10790327, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-10943838, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-13761500, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-156703, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-2105499, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-2297790, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-2415535, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-2428682, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-3058727, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-3668738, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-4132935, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-5097134, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-6224802, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-7593169, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-7663510, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-7667876, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-7698982, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-7736581, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-7984417, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-8191288, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-8279704, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-838889, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-8516294, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-8522608, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-8609169, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-8718680, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-8806, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-8866794, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-8887283, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-8936410, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-9114011, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-9171830, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-9176412, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-9192675, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-922836, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-9475731, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-9585416, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-9585417, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-9865700, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-9920666, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-9971734, http://linkedlifedata.com/resource/pubmed/commentcorrection/11062270-9971742
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0021-9525
pubmed:author
pubmed:issnType
Print
pubmed:day
30
pubmed:volume
151
pubmed:owner
NLM
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