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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1976-2-9
|
| pubmed:abstractText |
B and T cell populations were studied in blood and neoplastic tissues from 64 untreated and 23 treated patients with non-Hodgkin's lymphoma. This study was undertaken primarily to evaluate the relation of B and T cell markers in various lymphomas to the currently accepted morphologic classifications and to determine the utility of various tissues in defining the cell of origin of a lymphoma. When histologically involved blood, bone marrow, lymph nodes or body fluids were studied, a B or T cell origin of the lymphoma was identified in 26 of 28 (68 per cent) patients. A B cell origin was found in 17 adults classified as having nodular (N) or diffuse (D) poorly differentiated lymphocytic lymphoma (PDLL). One lymphoma of T cell origin was observed in an adult with poorly differentiated lymphocytic lymphoma-diffuse (PDLL-D). In contrast, all cases of PDLL-D in children were T cell in origin. The origin of American Burkitt's (stem cell) lymphoma in two children was the B cell. When histologically involved blood was studied, a B or T cell origin was demonstrated in 10 of 21 (48 percent) adults. Evidence of a monoclonal proliferation of B lymphocytes in the blood was found two adults with more than 7 per cent lymphoma cells in Wright-Giemsa stained blood smears. When neoplastic lymph nodes were studied, the diagnosis of a B cell lymphoma was made in 8 of 12 (67 per cent) adults. Study of surface markers on malignant cells in cerebrospinal or serosal fluids frequently revealed a B or T cell origin of the lymphoma. B and T lymphocyte numbers in the blood did not correlate with immunoglobulin or skin test abnormalities. Abnormalities in circulating B or T cell percentages at diagnosis were a poor prognostic sign in patients with PDLL-D.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0002-9343
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
59
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
674-85
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1106193-Adolescent,
pubmed-meshheading:1106193-Adult,
pubmed-meshheading:1106193-Aged,
pubmed-meshheading:1106193-B-Lymphocytes,
pubmed-meshheading:1106193-Burkitt Lymphoma,
pubmed-meshheading:1106193-Child,
pubmed-meshheading:1106193-Child, Preschool,
pubmed-meshheading:1106193-Female,
pubmed-meshheading:1106193-Fluorescent Antibody Technique,
pubmed-meshheading:1106193-Humans,
pubmed-meshheading:1106193-Immune Adherence Reaction,
pubmed-meshheading:1106193-Immunoglobulins,
pubmed-meshheading:1106193-Infant,
pubmed-meshheading:1106193-Leukocyte Count,
pubmed-meshheading:1106193-Lymph Nodes,
pubmed-meshheading:1106193-Lymphoma,
pubmed-meshheading:1106193-Male,
pubmed-meshheading:1106193-Middle Aged,
pubmed-meshheading:1106193-Skin,
pubmed-meshheading:1106193-T-Lymphocytes
|
| pubmed:year |
1975
|
| pubmed:articleTitle |
B and T cell lymphomas. Analysis of blood and lymph nodes in 87 patients.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|