Linked Life Data

11060234

Source:http://linkedlifedata.com/resource/pubmed/id/11060234

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
23
pubmed:dateCreated
2000-12-26
pubmed:abstractText
FTZ-F1, a member of the nuclear receptor superfamily, has been implicated in the activation of the segmentation gene fushi tarazu during early embryogenesis of Drosophila melanogaster. We found that an isoform of FTZ-F1, betaFTZ-F1, is expressed in the nuclei of almost all tissues slightly before the first and second larval ecdysis and before pupation. Severely affected ftz-f1 mutants display an embryonic lethal phenotype, but can be rescued by ectopic expression of betaFTZ-F1 during the period of endogenous betaFTZ-F1 expression in the wild type. The resulting larvae are not able to molt, but this activity is rescued again by forced expression of betaFTZ-F1, allowing progression to the next larval instar stage. On the other hand, premature expression of betaFTZ-F1 in wild-type larvae at mid-first instar or mid-second instar stages causes defects in the molting process. Sensitive periods were found to be around the time of peak ecdysteroid levels and slightly before the start of endogenous betaFTZ-F1 expression. A hypomorphic ftz-f1 mutant that arrests in the prepupal stage can also be rescued by ectopic, time-specific expression of betaFTZ-F1. Failure of salivary gland histolysis, one of the phenotypes of the ftz-f1 mutant, is rescued by forced expression of the ftz-f1 downstream gene BR-C during the late prepupal period. These results suggest that betaFTZ-F1 regulates genes associated with ecdysis and metamorphosis, and that the exact timing of its action in the ecdysone-induced gene cascade is important for proper development.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0950-1991
pubmed:author
pubmed:issnType
Print
pubmed:volume
127
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5083-92
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:11060234-Animals, pubmed-meshheading:11060234-Chromosome Mapping, pubmed-meshheading:11060234-DNA-Binding Proteins, pubmed-meshheading:11060234-Drosophila Proteins, pubmed-meshheading:11060234-Drosophila melanogaster, pubmed-meshheading:11060234-Female, pubmed-meshheading:11060234-Fushi Tarazu Transcription Factors, pubmed-meshheading:11060234-Gene Expression Profiling, pubmed-meshheading:11060234-Homeodomain Proteins, pubmed-meshheading:11060234-Insect Proteins, pubmed-meshheading:11060234-Larva, pubmed-meshheading:11060234-Male, pubmed-meshheading:11060234-Metamorphosis, Biological, pubmed-meshheading:11060234-Molting, pubmed-meshheading:11060234-Mutagenesis, pubmed-meshheading:11060234-Pupa, pubmed-meshheading:11060234-Receptors, Cytoplasmic and Nuclear, pubmed-meshheading:11060234-Salivary Glands, pubmed-meshheading:11060234-Steroidogenic Factor 1, pubmed-meshheading:11060234-Transcription Factors
pubmed:year
2000
pubmed:articleTitle
Temporally restricted expression of transcription factor betaFTZ-F1: significance for embryogenesis, molting and metamorphosis in Drosophila melanogaster.
pubmed:affiliation
Department of Genetics, The Graduate University for Advanced Studies, and Department of Developmental Genetics, National Institute of Genetics, Mishima, Shizuoka-ken 411-8540, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't