Linked Life Data

11059812

Source:http://linkedlifedata.com/resource/pubmed/id/11059812

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
pubmed:issue
9-10
pubmed:dateCreated
2001-2-14
pubmed:abstractText
Oxidative metabolism is very active in brain, where large amounts of chemical energy as ATP molecules are consumed, mostly required to maintain cellular Na+/K+ gradients through the participation of the sodium pump (Na+,K+-ATPase), whose activity is selectively and potently inhibited by the alkaloid ouabain. Na+/K+ gradients are involved in nerve impulse propagation, in neurotransmitter release and cation homeostasis in the nervous system. Likewise, enzyme activity modulation is crucial for maintaining normal blood pressure and cardiovascular contractility as well as renal sodium excretion. The present article reviews the progress in disclosing putative ouabain-like substances, examines their denomination according to different research teams, tissue or biological fluid sources, extraction and purification, assays, biological properties and chemical and biophysical features. When data is available, comparison with ouabain itself is mentioned. Likewise, their potential action in normal physiology as well as in experimental and human pathology is summarized.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0364-3190
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1421-30
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
How many endobains are there?
pubmed:affiliation
Instituto de Biología Celular y Neurociencias Prof. Eduardo De Robertis, PROBICENE-CONICET, Facultad de Medicina, Universidad de Buenos Aires, Paraguay, Buenos Aires, Argentina. grodrig@ffyb.uba.ar
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't