Linked Life Data

1105912

Source:http://linkedlifedata.com/resource/pubmed/id/1105912

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1976-2-20
pubmed:abstractText
The immunologic status of dogs undergoing bladder carcinogenesis with 4-amino-biphenyl and normal littermate controls is being evaluated. Studies using blastogenic transformation, nonimmune cytotoxic reactions, and rosette formation have revealed that dogs possess lymphocytes that have some properties similar to those of B and T cells of other species. Since tumors are now just appearing and hence are not yet available for specific immunologic determinations, the assessments had to be limited for the present to other types of antigens and mitogens (yeast, red blood cells and plant lectins). No major changes in reactions of cells from the carcinogenized animals have yet been observed during the preneoplastic phase as measured by phagocytosis, migration inhibition, or cytotoxicity tests, although a trend to lower blastogenic responses was noted. It yet remains to be seen whether lower lymphocyte responses to mitogens in carcinogenized dogs are of prognostic value for the early detection of tumors of the bladder.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0041-1345
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
495-501
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Urinary bladder carcinogenesis in the dog: preliminary studies on cellular immunity.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.