Linked Life Data

11058802

Source:http://linkedlifedata.com/resource/pubmed/id/11058802

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2000-11-17
pubmed:abstractText
Astrocytes rarely undergo mitotic cell division in the developed adult. However, following injury to the central nervous system (CNS), astrocytes undergo rapid cell division and reactive astrocytes encapsulate exposed areas of the CNS producing a glial scar. Studies indicate the existence of a family of epidermal growth factor receptor (EGFr) related glycosidic mitogen inhibitors with growth inhibiting properties for astrocytes. Here, for the first time, we describe the isolation of such a factor from cultured rat astrocytes by ion-exchange and immunoaffinity chromatography. The isolated factor is glycosidic in nature, cross reacts with the anti-EGFr monoclonal antibody Clone 29.1, and inhibits the growth of primary astrocytes and N2a neuroblastoma cells in vitro.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
17
pubmed:volume
294
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
121-4
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Isolation and purification of an epidermal growth factor receptor-related inhibitor of cell growth from cultured rat astrocytes.
pubmed:affiliation
National Diagnostics Centre, BioResearch Ireland, c/o National University of Ireland, Galway, Ireland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't