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rdf:type |
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lifeskim:mentions |
umls-concept:C0012854,
umls-concept:C0020205,
umls-concept:C0022116,
umls-concept:C0026336,
umls-concept:C0034493,
umls-concept:C0040648,
umls-concept:C0205263,
umls-concept:C0302600,
umls-concept:C0679058,
umls-concept:C0733688,
umls-concept:C0965644,
umls-concept:C1333897,
umls-concept:C1522391,
umls-concept:C1547699,
umls-concept:C1704838,
umls-concept:C2700640
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pubmed:issue |
18
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pubmed:dateCreated |
2000-11-6
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pubmed:abstractText |
Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric transcription factor that regulates expression of genes involved in O(2) homeostasis, including vascular endothelial growth factor (VEGF), a potent stimulator of angiogenesis. We sought to exploit this native adaptive response to hypoxia as a treatment for chronic ischemia.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Endothelial Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Erythropoietin,
http://linkedlifedata.com/resource/pubmed/chemical/Herpes Simplex Virus Protein Vmw65,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoxia-Inducible Factor 1,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoxia-Inducible Factor 1, alpha...,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphokines,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Vaccines, DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
31
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pubmed:volume |
102
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2255-61
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11056102-Angiography,
pubmed-meshheading:11056102-Animals,
pubmed-meshheading:11056102-Blood Pressure,
pubmed-meshheading:11056102-Cell Line,
pubmed-meshheading:11056102-Collateral Circulation,
pubmed-meshheading:11056102-DNA-Binding Proteins,
pubmed-meshheading:11056102-Endothelial Growth Factors,
pubmed-meshheading:11056102-Erythropoietin,
pubmed-meshheading:11056102-Feasibility Studies,
pubmed-meshheading:11056102-Gene Therapy,
pubmed-meshheading:11056102-Hematocrit,
pubmed-meshheading:11056102-Herpes Simplex Virus Protein Vmw65,
pubmed-meshheading:11056102-Hindlimb,
pubmed-meshheading:11056102-Hypoxia-Inducible Factor 1,
pubmed-meshheading:11056102-Hypoxia-Inducible Factor 1, alpha Subunit,
pubmed-meshheading:11056102-Injections, Intramuscular,
pubmed-meshheading:11056102-Ischemia,
pubmed-meshheading:11056102-Lymphokines,
pubmed-meshheading:11056102-Male,
pubmed-meshheading:11056102-Neovascularization, Physiologic,
pubmed-meshheading:11056102-Nuclear Proteins,
pubmed-meshheading:11056102-Rabbits,
pubmed-meshheading:11056102-Recombinant Fusion Proteins,
pubmed-meshheading:11056102-Regional Blood Flow,
pubmed-meshheading:11056102-Transcription Factors,
pubmed-meshheading:11056102-Transcriptional Activation,
pubmed-meshheading:11056102-Transfection,
pubmed-meshheading:11056102-Vaccines, DNA,
pubmed-meshheading:11056102-Vascular Endothelial Growth Factor A,
pubmed-meshheading:11056102-Vascular Endothelial Growth Factors
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pubmed:year |
2000
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pubmed:articleTitle |
Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1alpha/VP16 hybrid transcription factor.
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pubmed:affiliation |
Genzyme Corp, Framingham, MA, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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