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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2000-12-11
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pubmed:abstractText |
Upon the binding of their ligands, G protein-coupled receptors couple to the heterotrimeric G proteins to transduce a signal. One receptor family may couple to a single G protein subtype and another family to several ones. Is there a signal in the receptor sequence that can give an indication of the G protein subtype selectivity? We used a sequence analysis method on biogenic amine and adenosine receptors and concluded that a weak signal can be detected in receptor families where specialization for coupling to a given G protein occurred during a recent divergent evolutionary process. Proteins 2000;41:448-459.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Biogenic Amine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Muscarinic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Purinergic P1
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0887-3585
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2000 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
448-59
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11056033-Algorithms,
pubmed-meshheading:11056033-Animals,
pubmed-meshheading:11056033-Base Sequence,
pubmed-meshheading:11056033-Conserved Sequence,
pubmed-meshheading:11056033-Databases, Factual,
pubmed-meshheading:11056033-Evolution, Molecular,
pubmed-meshheading:11056033-GTP-Binding Proteins,
pubmed-meshheading:11056033-Humans,
pubmed-meshheading:11056033-Ligands,
pubmed-meshheading:11056033-Molecular Sequence Data,
pubmed-meshheading:11056033-Mutation,
pubmed-meshheading:11056033-Phylogeny,
pubmed-meshheading:11056033-Receptors, Adrenergic,
pubmed-meshheading:11056033-Receptors, Biogenic Amine,
pubmed-meshheading:11056033-Receptors, Cell Surface,
pubmed-meshheading:11056033-Receptors, Muscarinic,
pubmed-meshheading:11056033-Receptors, Purinergic P1,
pubmed-meshheading:11056033-Signal Transduction
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pubmed:year |
2000
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pubmed:articleTitle |
Receptors coupling to G proteins: is there a signal behind the sequence?
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pubmed:affiliation |
BIOcomputing, European Molecular Biology Laboratory, Heidelberg, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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