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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
20
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pubmed:dateCreated |
2001-2-20
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pubmed:abstractText |
A series of pyrrolo[2,1,5-cd]indolizine derivatives has been synthesized and evaluated as ligands for the estrogen receptor. Properly substituted mono- and di-hydroxy derivatives showed binding in the low nanomolar range in accordance with their structural resemblance to estrogen.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0960-894X
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2383-6
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:11055361-Drug Design,
pubmed-meshheading:11055361-Estradiol,
pubmed-meshheading:11055361-Humans,
pubmed-meshheading:11055361-Indolizines,
pubmed-meshheading:11055361-Kinetics,
pubmed-meshheading:11055361-Models, Molecular,
pubmed-meshheading:11055361-Molecular Conformation,
pubmed-meshheading:11055361-Molecular Structure,
pubmed-meshheading:11055361-Pyrroles,
pubmed-meshheading:11055361-Receptors, Estrogen,
pubmed-meshheading:11055361-Structure-Activity Relationship
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pubmed:year |
2000
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|
pubmed:articleTitle |
Synthesis and estrogen receptor binding affinities of novel pyrrolo[2,1,5-cd]indolizine derivatives.
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pubmed:affiliation |
Health Care Discovery and Preclinical Development, Novo Nordisk A/S, Målov, Denmark. asj@novo.dk
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pubmed:publicationType |
Journal Article
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