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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
20
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pubmed:dateCreated |
2001-2-20
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pubmed:abstractText |
Tetrahydroisoquinoline derivatives containing a 4-(hexylureido)benzenesulfonamide were examined as human beta3 adrenergic receptor (AR) agonists. Notably, 4,4-biphenyl derivative 9 was a 6 nM full agonist of the beta3 AR. Naphthyloxy compound 18 (beta3 EC50 = 78 nM) did not activate the beta1 and beta2 ARs at 10 microM, and showed >1000-fold selectivity over binding to the beta1 and beta2 ARs.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-3 Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Amides,
http://linkedlifedata.com/resource/pubmed/chemical/Isoquinolines,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta-1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta-2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta-3,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:BrockunierL LLL,
pubmed-author:CandeloreM RMR,
pubmed-author:CascieriM AMA,
pubmed-author:DenkHH,
pubmed-author:FOXJ NJN,
pubmed-author:FisherM HMH,
pubmed-author:LieII,
pubmed-author:ParmeeE RER,
pubmed-author:SinghS BSB,
pubmed-author:TothKK,
pubmed-author:WeberA EAE,
pubmed-author:WyvrattM JMJ
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pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2283-6
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:11055339-Adrenergic beta-3 Receptor Antagonists,
pubmed-meshheading:11055339-Adrenergic beta-Agonists,
pubmed-meshheading:11055339-Amides,
pubmed-meshheading:11055339-Drug Design,
pubmed-meshheading:11055339-Humans,
pubmed-meshheading:11055339-Isoquinolines,
pubmed-meshheading:11055339-Models, Molecular,
pubmed-meshheading:11055339-Molecular Conformation,
pubmed-meshheading:11055339-Peptides,
pubmed-meshheading:11055339-Receptors, Adrenergic, beta-1,
pubmed-meshheading:11055339-Receptors, Adrenergic, beta-2,
pubmed-meshheading:11055339-Receptors, Adrenergic, beta-3,
pubmed-meshheading:11055339-Recombinant Proteins,
pubmed-meshheading:11055339-Structure-Activity Relationship
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pubmed:year |
2000
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pubmed:articleTitle |
Tetrahydroisoquinoline derivatives containing a benzenesulfonamide moiety as potent, selective human beta3 adrenergic receptor agonists.
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pubmed:affiliation |
Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA. emma_parmee@merck.com
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pubmed:publicationType |
Journal Article
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