Linked Life Data

11054573

Source:http://linkedlifedata.com/resource/pubmed/id/11054573

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2000-12-6
pubmed:databankReference
pubmed:abstractText
This paper reports the characterization of the human tubulin tyrosine ligase-like 1 gene (TTLL1), which maps to the chromosome region 22q13.1 and has been partially duplicated on three other acrocentric chromosomes: 13, 15 and 21. We describe the complete cDNA, TTLL1a, coding for the putative 423 amino acid long TTLL1 and alternative transcripts coding for truncated TTLL1. Likely TTLL1a corresponds to the 1.8 kb transcript that was detected in a wide range of tissues and has a stronger expression in heart, brain and testis. A 4.8 kb transcript was found only in brain tissues. We present an interspecies sequence comparison, revealing three conserved domains, named TTLD1, TTLD2 and TTLD3, that are specific to the TTLs and TTL-like proteins.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0378-1119
pubmed:author
pubmed:issnType
Print
pubmed:day
17
pubmed:volume
257
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
109-17
pubmed:dateRevised
2007-4-27
pubmed:meshHeading
pubmed-meshheading:11054573-Alternative Splicing, pubmed-meshheading:11054573-Amino Acid Sequence, pubmed-meshheading:11054573-Base Sequence, pubmed-meshheading:11054573-Blotting, Northern, pubmed-meshheading:11054573-Chromosome Mapping, pubmed-meshheading:11054573-Chromosomes, Human, Pair 22, pubmed-meshheading:11054573-DNA, Complementary, pubmed-meshheading:11054573-Exons, pubmed-meshheading:11054573-Expressed Sequence Tags, pubmed-meshheading:11054573-Female, pubmed-meshheading:11054573-Genes, pubmed-meshheading:11054573-Humans, pubmed-meshheading:11054573-Introns, pubmed-meshheading:11054573-Male, pubmed-meshheading:11054573-Molecular Sequence Data, pubmed-meshheading:11054573-Peptide Synthases, pubmed-meshheading:11054573-Polymerase Chain Reaction, pubmed-meshheading:11054573-Pseudogenes, pubmed-meshheading:11054573-RNA, Messenger, pubmed-meshheading:11054573-Radiation Hybrid Mapping, pubmed-meshheading:11054573-Sequence Alignment, pubmed-meshheading:11054573-Sequence Analysis, DNA, pubmed-meshheading:11054573-Sequence Homology, Amino Acid, pubmed-meshheading:11054573-Tissue Distribution
pubmed:year
2000
pubmed:articleTitle
Characterization of the human tubulin tyrosine ligase-like 1 gene (TTLL1) mapping to 22q13.1.
pubmed:affiliation
Séquences Répétées et Centromères Humains, CNRS UPR 1142, Institut de Biologie, 4, bv Henri IV, 34060, Montpellier, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't