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pubmed-article:11054381pubmed:abstractTextNonimmune mechanisms of mucosal defense seem to be biologically important and might explain the observed variability in the course of enteric infection in immunodeficiency. Mannose-binding lectin (MBL) deficiency is associated with persistent diarrhea in children. We found that genetic determinants of MBL deficiency appear to predispose to cryptosporidiosis in patients with the acquired immunodeficiency syndrome (AIDS), and went on to study interactions of MBL and complement on Cryptosporidium parvum sporozoites.lld:pubmed
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pubmed-article:11054381pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:11054381pubmed:articleTitleMannose-binding lectin is a component of innate mucosal defense against Cryptosporidium parvum in AIDS.lld:pubmed
pubmed-article:11054381pubmed:affiliationDigestive Diseases Research Centre, St. Bartholomew's and Royal London School of Medicine and Dentistry, London, England. mpkelly@mds.qmw.ac.uklld:pubmed
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