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rdf:type |
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lifeskim:mentions |
umls-concept:C0001175,
umls-concept:C0026724,
umls-concept:C0065661,
umls-concept:C0085319,
umls-concept:C0449432,
umls-concept:C0449435,
umls-concept:C1179435,
umls-concept:C1524073,
umls-concept:C1548799,
umls-concept:C1705248,
umls-concept:C1880266
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pubmed:issue |
5
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|
pubmed:dateCreated |
2000-11-27
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|
pubmed:abstractText |
Nonimmune mechanisms of mucosal defense seem to be biologically important and might explain the observed variability in the course of enteric infection in immunodeficiency. Mannose-binding lectin (MBL) deficiency is associated with persistent diarrhea in children. We found that genetic determinants of MBL deficiency appear to predispose to cryptosporidiosis in patients with the acquired immunodeficiency syndrome (AIDS), and went on to study interactions of MBL and complement on Cryptosporidium parvum sporozoites.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0016-5085
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
119
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1236-42
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11054381-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:11054381-Animals,
pubmed-meshheading:11054381-Blood Proteins,
pubmed-meshheading:11054381-Carrier Proteins,
pubmed-meshheading:11054381-Collectins,
pubmed-meshheading:11054381-Complement Activation,
pubmed-meshheading:11054381-Complement C4,
pubmed-meshheading:11054381-Cross-Sectional Studies,
pubmed-meshheading:11054381-Cryptosporidiosis,
pubmed-meshheading:11054381-Cryptosporidium parvum,
pubmed-meshheading:11054381-Duodenum,
pubmed-meshheading:11054381-Humans,
pubmed-meshheading:11054381-Immunoblotting,
pubmed-meshheading:11054381-Intestinal Diseases,
pubmed-meshheading:11054381-Intestinal Mucosa,
pubmed-meshheading:11054381-Mannose-Binding Protein-Associated Serine Proteases,
pubmed-meshheading:11054381-Phenotype,
pubmed-meshheading:11054381-Serine Endopeptidases
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pubmed:year |
2000
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pubmed:articleTitle |
Mannose-binding lectin is a component of innate mucosal defense against Cryptosporidium parvum in AIDS.
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pubmed:affiliation |
Digestive Diseases Research Centre, St. Bartholomew's and Royal London School of Medicine and Dentistry, London, England. mpkelly@mds.qmw.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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